Schuyler M, Schmitt D, Steinberg D
Int Arch Allergy Appl Immunol. 1982;68(2):112-6. doi: 10.1159/000233078.
A model of hypersensitivity pneumonitis (HP) in syngeneic animals would allow experiments designed to determine immunopathogenesis of HP. Strain II guinea pigs were treated with Micropolyspora faeni and challenged with intratracheal M. faeni. Skin test, serum antibody, hilar lymph node lymphocyte proliferation and bronchoalveolar macrophage migration inhibition (MMI) response to M. faeni antigen were determined. Sensitized animals had positive delayed skin tests, serum antibody and bronchoalveolar cell MMI, but not M. faeni-induced hilar node lymphocyte proliferation. We conclude that this model is suitable for examination of the importance of various mechanisms which might be important in HP.
同基因动物的超敏性肺炎（HP）模型将有助于开展旨在确定HP免疫发病机制的实验。用嗜热放线菌对II系豚鼠进行处理，然后经气管内注射嗜热放线菌进行激发。测定了皮肤试验、血清抗体、肺门淋巴结淋巴细胞增殖以及对嗜热放线菌抗原的支气管肺泡巨噬细胞迁移抑制（MMI）反应。致敏动物的迟发性皮肤试验、血清抗体和支气管肺泡细胞MMI呈阳性，但嗜热放线菌诱导的肺门淋巴结淋巴细胞增殖呈阴性。我们得出结论，该模型适用于研究在HP中可能起重要作用的各种机制的重要性。
