Orbach-Arbouys S, Andrade-Mena C E, Berardet M, Mathe G
Int Arch Allergy Appl Immunol. 1982;68(2):117-21. doi: 10.1159/000233079.
After the intraperitoneal injection of aclacinomycin into mice, a variety of immune responses were increased. The total plaque-forming spleen cell response to SRBC was higher in treated animals than in controls, in spite of an apparent cytotoxic effects on B cells. The aclacinomycin-sensitive cell is apparently a long-lived cell, surviving adult thymectomy. Delayed-type hypersensitivity reactions were also augmented in treated animals, particularly those bearing tumors. In adjuvant-treated mice, the injection of aclacinomycin augments the immune response still further. Such observations should be taken into account in the establishment of clinical protocols associating immunotherapy and chemotherapy.
给小鼠腹腔注射阿克拉霉素后，多种免疫反应增强。尽管对B细胞有明显的细胞毒性作用，但经处理的动物对SRBC的总噬斑形成脾细胞反应高于对照组。阿克拉霉素敏感细胞显然是一种长寿细胞，成年胸腺切除术后仍能存活。经处理的动物，尤其是患有肿瘤的动物，迟发型超敏反应也增强。在佐剂处理的小鼠中，注射阿克拉霉素可进一步增强免疫反应。在制定免疫治疗与化疗联合的临床方案时应考虑到这些观察结果。
