Wallenburg H C
Int J Biol Res Pregnancy. 1981;2(1):15-22.
The objective of this article is to present an evaluation of the problems encountered in assessing the effects of prostaglandins (PGs) on the uteroplacental vasculature and circulation as well as to review pertinent experimental data. Problems in the measurement of uteroplacental blood flow are mainly due to biologic differences between placentation in different species. The physiologic role of PGs in the modulation and regulation of uterine and placental blood flows is difficult to investigate because PGs are local hormones. In addition, the direct effects of PGs on the uteroplacental circulation cannot be easily distinguished from the indirect effects due to myometrial contractions and interactions with other vasoactive substances. There is some experimental evidence that the dilation of the uteroplacental vasculature during pregnancy could be a result of the physiologic balance of local vasodilator PGs produced in the uterine vessels and vasoconstrictor effects of circulating vasoactive substances. The role of prostacyclin as well as that of platelet-thromboxane A2 in the physiologic regulation of uteroplacental blood flow remains to be elucidated, in particular in primates.
本文的目的是对评估前列腺素（PGs）对子宫胎盘血管系统和循环系统的影响时遇到的问题进行评估，并回顾相关实验数据。子宫胎盘血流测量中的问题主要源于不同物种胎盘形成的生物学差异。由于PGs是局部激素，其在调节子宫和胎盘血流中的生理作用难以研究。此外，PGs对子宫胎盘循环的直接作用不易与因子宫肌层收缩以及与其他血管活性物质相互作用产生的间接作用区分开来。有一些实验证据表明，孕期子宫胎盘血管舒张可能是子宫血管中产生的局部血管舒张性PGs与循环血管活性物质的血管收缩作用之间生理平衡的结果。前列环素以及血小板血栓素A2在子宫胎盘血流生理调节中的作用仍有待阐明，尤其是在灵长类动物中。
