Day T H, Dobson T, Hillier P C, Parkin D T, Clarke B
Heredity (Edinb). 1982 Feb;48(Pt 1):35-44. doi: 10.1038/hdy.1982.4.
Populations of seaweed fly Coelopa frigida are polymorphic at three loci determining the enzymes peptidase-1 (Pep-1), alcohol dehydrogenase (Adh) and larval esterase-2 (Es-2). Alleles at these loci have been shown by others to be non-randomly associated with each other. In the present paper we report non-random associations between the Adh and Es-2 loci and inversions on chromosome I. The two common alleles Adh-B and D are in strong linkage disequilibrium with the alpha and beta inversions, but the Adh-A and C alleles are not so. The X and Y alleles at the Es-2 locus show weak, but still significant, associations with the inversions. We consider possible linkage relationships of the loci on the chromosomal arrangements, and discuss the hypothesis that they constitute part of a coadapted gene complex whose members code for functionally related enzymes.
海草蝇（Coelopa frigida）群体在决定肽酶 -1（Pep -1）、乙醇脱氢酶（Adh）和幼虫酯酶 -2（Es -2）这三种酶的三个基因座上具有多态性。其他人已表明这些基因座上的等位基因彼此之间存在非随机关联。在本文中，我们报告了Adh和Es -2基因座与一号染色体倒位之间的非随机关联。两个常见等位基因Adh -B和D与α和β倒位处于强连锁不平衡状态，但Adh -A和C等位基因并非如此。Es -2基因座上的X和Y等位基因与倒位呈现出较弱但仍显著的关联。我们考虑了染色体排列上这些基因座可能的连锁关系，并讨论了这样一种假说，即它们构成了一个共同适应的基因复合体的一部分，其成员编码功能相关的酶。
