Hoppe R T, Dorie M J
J Immunol. 1982 Jun;128(6):2387-9.
C3H/Km (H-2k) mice were treated with fractionated total lymphoid irradiation (TLI) (17 x 200 rad) and then were inoculated with 3 x 10(6) tumor cells from the EMT6 tumor cell line derived from the BALB/c (H-2d) mouse. One group of mice also received an i.v. infusion of BALB/c bone marrow (3 x 10(7) cells). Tumors in control animals (no TLI) became palpable within 10 days after inoculation, but subsequent tumor regression was rapid, with complete disappearance in all animals by 23 days. Initial tumor growth was exponential in both groups of mice treated with TLI, but tumors regressed after 30 days in the animals treated with TLI alone. In the group treated with TLI and bone marrow infusion exponential tumor growth continued until pulmonary metastases developed and all animals died. The TLI-treated mouse provides a model for tumor allografting. Further development of this model may demonstrate its efficacy in human tumor xenotransplantation.
将C3H/Km（H-2k）小鼠进行分次全身淋巴照射（TLI）（17×200拉德），然后接种来自BALB/c（H-2d）小鼠的EMT6肿瘤细胞系的3×10⁶个肿瘤细胞。一组小鼠还静脉输注了BALB/c骨髓（3×10⁷个细胞）。对照动物（未进行TLI）接种后10天内肿瘤可触及，但随后肿瘤迅速消退，所有动物在23天时肿瘤完全消失。在两组接受TLI治疗的小鼠中，初始肿瘤生长呈指数增长，但仅接受TLI治疗的动物在30天后肿瘤消退。在接受TLI和骨髓输注治疗的组中，肿瘤呈指数增长持续到发生肺转移，所有动物死亡。经TLI治疗的小鼠提供了一种肿瘤同种异体移植模型。该模型的进一步发展可能证明其在人类肿瘤异种移植中的有效性。
