Uhlman D L, Jones G W
J Gen Microbiol. 1982 Feb;128(2):415-8. doi: 10.1099/00221287-128-2-415.
HeLa cells damaged by exposure to low pH released a diffusible attractant which greatly increased the collision frequency and hence the attachment of chemotactic Salmonella typhimurium. The attractant was tentatively identified as glycine. In contrast, when undamaged HeLa cells were used, no difference was found between a chemotactic parent strain and a non-chemotactic mutant in collision frequency or attachment. It is suggested that factors increasing cell membrane permeability could attract S. typhimurium to host cells in vivo.
暴露于低pH值环境而受损的海拉细胞释放出一种可扩散的引诱剂，这种引诱剂大大增加了趋化性鼠伤寒沙门氏菌的碰撞频率，从而增加了其附着。这种引诱剂初步鉴定为甘氨酸。相比之下，当使用未受损的海拉细胞时，趋化性亲本菌株和非趋化性突变体在碰撞频率或附着方面没有差异。有人提出，增加细胞膜通透性的因素可能会在体内将鼠伤寒沙门氏菌吸引到宿主细胞。
