Hené R J, Boer P, Koomans H A, Mees E J
Kidney Int. 1982 Jan;21(1):98-101. doi: 10.1038/ki.1982.14.
The disagreement in the literature concerning the role of aldosterone in the maintenance of potassium homeostasis in chronic renal disease might be partially explained by differences in plasma renin activity (PRA) among individual patients. Therefore, a study was done in 28 selected patients with varying degrees of renal insufficiency whose serum potassium and PRA concentrations were within the normal range. The results indicate that at comparable serum potassium and PRA concentrations, plasma aldosterone is in most instances elevated when creatinine clearance is lower than 50% of normal.
文献中关于醛固酮在慢性肾病钾稳态维持中作用的分歧，可能部分归因于个体患者血浆肾素活性（PRA）的差异。因此，对28例选定的肾功能不全程度各异且血清钾和PRA浓度在正常范围内的患者进行了一项研究。结果表明，在血清钾和PRA浓度相当的情况下，当肌酐清除率低于正常的50%时，大多数情况下血浆醛固酮会升高。
