Schoeny R
Mutat Res. 1982 Mar;101(1):45-56. doi: 10.1016/0165-1218(82)90164-1.
4 chlorinated biphenyl and 5 chlorinated dibenzofuran compounds have been evaluated in the reversion assay developed by B.N Ames using Salmonella typhimurium histidine auxotrophs. All these compounds (2,4,2'-4'-tetrachlorobiphenyl, 3,4,3',4'-tetrachlorobiphenyl, 4-chlorobiphenyl, 2,4,,6,2',4',6'-hexachlorobiphenyl, dibenzofuran, 2,9-dichlorodibenzofuran, 3,6-dichlorodibenzofuran, 2,3,7,8-tetrachlorodibenzofuran and octachlorodibenzofuran) were nonmutagenic for strains TA98 and TA100 when tested over a 3-log dose range. They were also not mutagenic whether or not varying concentrations of microsomal extracts (S9) from uninduced rats or from rats induced by several methods were included in the experimental protocol.
4种氯化联苯和5种氯化二苯并呋喃化合物已在由B.N. 艾姆斯开发的回复突变试验中进行了评估，该试验使用鼠伤寒沙门氏菌组氨酸营养缺陷型菌株。所有这些化合物（2,4,2'-4'-四氯联苯、3,4,3',4'-四氯联苯、4-氯联苯、2,4,,6,2',4',6'-六氯联苯、二苯并呋喃、2,9-二氯二苯并呋喃、3,6-二氯二苯并呋喃、2,3,7,8-四氯二苯并呋喃和八氯二苯并呋喃）在3个对数剂量范围内进行测试时，对TA98和TA100菌株无致突变性。无论实验方案中是否包含来自未诱导大鼠或经多种方法诱导的大鼠的不同浓度微粒体提取物（S9），它们也都无致突变性。
