氯化烃类物质多氯联苯混合物1254、1,2,4-三氯苯、灭蚁灵和开蓬对沙门氏菌无致突变性。
Non-mutagenicity for Salmonella of the chlorinated hydrocarbons aroclor 1254, 1,2,4-trichlorobenzene, mirex and kepone.
作者信息
Schoeny R S, Smith C C, Loper J C
出版信息
Mutat Res. 1979 Oct;68(2):125-32. doi: 10.1016/0165-1218(79)90140-x.
A polychlorinated biphenyl mixture, Aroclor 1254, two commercial grade insecticides, mirex and kepone, and a pesticide breakdown product, 1,2,4-trichlorobenzene were evaluated for mutagenicity and hepatic enzyme induction potential in the Salmonella/microsomal assay. None was found to revert strains TA1535, TA1537, TA98 or TA100 when tested with or without metabolic activation. Liver microsomal extracts (S9) from rats induced with 1,2,4-trichlorobenzene were shown to differ from S9 of either control or Aroclor 1254-induced rats in the capacity to activate 2-aminoanthracene mutagenesis.
对一种多氯联苯混合物（Aroclor 1254）、两种商业级杀虫剂（灭蚁灵和开蓬）以及一种农药分解产物（1,2,4-三氯苯）进行了沙门氏菌/微粒体试验，以评估其致突变性和肝酶诱导潜力。在有或无代谢活化的情况下进行测试时，未发现任何一种物质能使TA1535、TA1537、TA98或TA100菌株发生回复突变。结果表明，用1,2,4-三氯苯诱导的大鼠肝脏微粒体提取物（S9）在激活2-氨基蒽致突变性的能力方面，与对照大鼠或Aroclor 1254诱导的大鼠的S9不同。
Zotero 插件