Starkova N T, Lobanova A M, Negovskaia A V, Letova E K
Probl Endokrinol (Mosk). 1982 Mar-Apr;28(2):12-6.
Several indices of fat and carbohydrate metabolism were examined in 9 patients with congenital generalized lipodystrophy and in 11 subjects with the hypermuscular form of the disease. The latent or manifest disorders of carbohydrate metabolism, hyperinsulinism, hypercholesterolemia, hypertriglyceridemia, lipid spectrum displacement towards pre-beta-lipoproteid fraction were seen in the majority of patients. Disturbed fat metabolism was more pronounced in patients with hypermuscular lipodystrophy. In lipoatrophic states there was no correlation between immunoreactive insulin level and triglyceride concentration in the blood plasma.
对9例先天性全身性脂肪营养不良患者和11例患有该疾病的肌肉发达型患者的几种脂肪和碳水化合物代谢指标进行了检查。大多数患者出现了潜在或明显的碳水化合物代谢紊乱、高胰岛素血症、高胆固醇血症、高甘油三酯血症以及脂质谱向前β-脂蛋白部分的偏移。脂肪代谢紊乱在肌肉发达型脂肪营养不良患者中更为明显。在脂肪萎缩状态下，血浆中免疫反应性胰岛素水平与甘油三酯浓度之间没有相关性。
