血清胆固醇和甘油三酯浓度升高的受试者在低脂饮食和富含单烯酸饮食后的胰岛素敏感性。

Insulin sensitivity after a reduced-fat diet and a monoene-enriched diet in subjects with elevated serum cholesterol and triglyceride concentrations.

作者信息

Louheranta A M, Schwab U S, Sarkkinen E S, Voutilainen E T, Ebeling T M, Erkkilä A T, Turpeinen A K, Uusitupa M I

机构信息

Department of Clinical Nutrition, University of Kuopio, Finland.

出版信息

Nutr Metab Cardiovasc Dis. 2000 Aug;10(4):177-87.

PMID:11079255

Abstract

BACKGROUND AND AIMS

To investigate the effect of a reduced-fat diet and a monoene-enriched diet (MUFA diet) on serum lipids, glucose and insulin metabolism in subjects with elevated cholesterol and triglyceride concentrations.

METHODS AND RESULTS

Eighteen subjects with elevated serum cholesterol and triglyceride concentrations consumed the MUFA diet (39% of energy (E%) as fat and 21 E% monoenes) and the reduced-fat diet (34 E% fat, 16 E% monoenes) for 4 weeks according to a randomized cross-over design. Both periods were preceded by consumption of a standardized baseline diet for 2 weeks. Serum lipid and lipoprotein concentrations were determined at the beginning and end of each diet period. A frequently sampled intravenous glucose tolerance test was performed after the MUFA diet and the reduced-fat diet. Insulin sensitivity index (SI) was 40% higher after the reduced-fat diet than after the MUFA diet (2.42 +/- 0.42 vs 1.73 +/- 0.24 10(-4) min-1 U-1 ml-1, p = 0.018). This change in insulin sensitivity was seen in 13 subjects and was most evident in those who began with the MUFA diet. Compared to the baseline diet (high in saturated fat), both experimental diets lowered serum total and LDL cholesterol concentrations (6.6-6.9%, p < 0.05 and 7.4-8.0%, p < 0.05 respectively).

CONCLUSIONS

Both diets were equally effective in lowering serum lipid concentrations, but the reduced-fat diet resulted in better insulin sensitivity.

摘要

背景与目的

研究低脂饮食和富含单烯脂肪酸饮食（MUFA饮食）对胆固醇和甘油三酯浓度升高的受试者血清脂质、葡萄糖及胰岛素代谢的影响。

方法与结果

18名血清胆固醇和甘油三酯浓度升高的受试者按照随机交叉设计，分别食用MUFA饮食（脂肪供能占39%，单烯脂肪酸供能占21%）和低脂饮食（脂肪供能占34%，单烯脂肪酸供能占16%）4周。两个阶段之前均先食用标准化基线饮食2周。在每个饮食阶段开始和结束时测定血清脂质和脂蛋白浓度。在MUFA饮食和低脂饮食后进行频繁采样静脉葡萄糖耐量试验。低脂饮食后的胰岛素敏感性指数（SI）比MUFA饮食后高40%（2.42±0.42对1.73±0.24×10⁻⁴ min⁻¹ U⁻¹ ml⁻¹，p = 0.018）。13名受试者出现了这种胰岛素敏感性变化，且在以MUFA饮食开始的受试者中最为明显。与基线饮食（饱和脂肪含量高）相比，两种实验饮食均降低了血清总胆固醇和低密度脂蛋白胆固醇浓度（分别降低6.6 - 6.9%，p < 0.05和7.4 - 8.0%，p < 0.05）。