Ellis K J, Morgan W D, Zanzi I, Yasumura S, Vartsky D, Cohn S H
Am J Ind Med. 1980;1(3-4):339-48. doi: 10.1002/ajim.4700010310.
In vivo measurements of kidney and liver cadmium burdens were obtained in 82 industrially exposed workers and ten control subjects. Kidney cadmium levels ranged from 0.9 mg to 57 mg, and liver concentrations ranged from 0.8 ppm to 120 ppm for the industrial group. Comparison values for the control group were 0.4 mg to 11.8 mg for the kidney and 0.6 ppm to 7.9 ppm for the liver. A biphasic relationship between kidney Cd levels and liver Cd levels was observed. The kidney and liver Cd levels showed an increase until approximately a 40 ppm concentration was reached in the liver. Thereafter, the kidney levels decreased as the liver concentration continued to increase. The kidney cadmium level at which this change occurred was approximately 31 mg for the total kidney. Further estimates of the critical level, based on years of exposure and renal dysfunction (beta 2-microglobulin, proteinuria), yielded estimates of 31 mg to 42 mg cadmium (300-400 micrograms/gm for the renal cortex).
对82名职业暴露工人和10名对照受试者进行了肾脏和肝脏镉负荷的体内测量。工业组的肾脏镉水平在0.9毫克至57毫克之间，肝脏镉浓度在0.8 ppm至120 ppm之间。对照组的肾脏比较值为0.4毫克至11.8毫克，肝脏为0.6 ppm至7.9 ppm。观察到肾脏镉水平与肝脏镉水平之间存在双相关系。在肝脏镉浓度达到约40 ppm之前，肾脏和肝脏的镉水平均呈上升趋势。此后，随着肝脏浓度继续升高，肾脏镉水平下降。发生这种变化时的肾脏镉水平，整个肾脏约为31毫克。根据暴露年限和肾功能障碍（β2-微球蛋白、蛋白尿）对临界水平进行的进一步估计，得出镉的估计值为31毫克至42毫克（肾皮质为300-400微克/克）。
