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相似文献

1
Metallothionein and occupational exposure to cadmium.金属硫蛋白与职业性镉暴露
Br J Ind Med. 1983 Aug;40(3):305-13. doi: 10.1136/oem.40.3.305.
2
The effects of low doses of cadmium-metallothionein on the renal uptake of beta 2-microglobulin in rats.低剂量镉-金属硫蛋白对大鼠肾脏摄取β2-微球蛋白的影响。
Toxicol Appl Pharmacol. 1987 Mar 15;87(3):440-5. doi: 10.1016/0041-008x(87)90249-3.
3
[Relationship between plasma anti-metallothionein antibody and renal dysfunction in cadmium exposed workers].[镉接触工人血浆抗金属硫蛋白抗体与肾功能障碍的关系]
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Jan;24(1):7-11.
4
Cadmium Complexed with β2-Microglubulin, Albumin and Lipocalin-2 rather than Metallothionein Cause Megalin:Cubilin Dependent Toxicity of the Renal Proximal Tubule.镉与β2-微球蛋白、白蛋白和脂联素-2形成复合物，而不是金属硫蛋白，导致巨球蛋白：内收蛋白依赖性肾近端小管毒性。
Int J Mol Sci. 2019 May 14;20(10):2379. doi: 10.3390/ijms20102379.
5
Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice.长期联合接触镉和砷会加剧肾毒性，尤其是在金属硫蛋白-I/II基因敲除小鼠中。
Toxicology. 2000 Jul 5;147(3):157-66. doi: 10.1016/s0300-483x(00)00194-3.
6
Significance of urinary metallothionein in workers exposed to cadmium.尿金属硫蛋白在镉暴露工人中的意义。
Int Arch Occup Environ Health. 1983;52(2):159-66. doi: 10.1007/BF00405419.
7
Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity.金属硫蛋白-I/II基因敲除小鼠对慢性口服镉诱导的肾毒性敏感。
Toxicol Sci. 2000 Sep;57(1):167-76. doi: 10.1093/toxsci/57.1.167.
8
Excretion of urinary cadmium, copper, and zinc in cadmium-exposed and nonexposed subjects, with special reference to urinary excretion of beta2-microglobulin and metallothionein.镉暴露和未暴露受试者尿镉、铜和锌的排泄，特别提及β2-微球蛋白和金属硫蛋白的尿排泄情况。
Biol Trace Elem Res. 2005 Winter;108(1-3):17-31. doi: 10.1385/bter:108:1-3:017.
9
A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2-microglobulin.金属硫蛋白 1A（MT1A）中的一个多态性与镉相关的尿β2-微球蛋白排泄有关。
Toxicol Appl Pharmacol. 2012 Dec 15;265(3):373-9. doi: 10.1016/j.taap.2012.09.006. Epub 2012 Sep 17.
10
Biliary excretion of cadmium in rat. VI. Mobilization of cadmium from metallothionein by 2,3-dimercaptopropanol.大鼠体内镉的胆汁排泄。VI. 二巯丙醇对金属硫蛋白中镉的动员作用。
J Toxicol Environ Health. 1980 Mar;6(2):393-401. doi: 10.1080/15287398009529859.

引用本文的文献

1
Histological demonstration of immunoreactive metallothionein in sections of human and rat tissue.组织切片中人类和大鼠组织免疫反应性金属硫蛋白的组织学显示。
Environ Geochem Health. 1985 Dec;7(4):127-30. doi: 10.1007/BF01786638.
2
Metallothionein: structure/antigenicity and detection/quantitation in normal physiological fluids.金属硫蛋白：正常生理体液中的结构/抗原性及检测/定量
Environ Health Perspect. 1984 Mar;54:117-27. doi: 10.1289/ehp.8454117.
3
A problem in looking for relationships between concentrations of urinary components.寻找尿液成分浓度之间关系时存在的一个问题。
Br J Ind Med. 1985 Jan;42(1):70-1. doi: 10.1136/oem.42.1.70.
4
Occupational exposure to cadmium: effect on metallothionein and other biological indices of exposure and renal function.职业性镉暴露：对金属硫蛋白及其他暴露生物学指标和肾功能的影响。
Arch Toxicol. 1987 Feb;59(5):360-4. doi: 10.1007/BF00295090.
5
Chronic cadmium intake results in dose-related excretion of metallothionein in urine.长期摄入镉会导致尿中金属硫蛋白的排泄量与剂量相关。
Experientia. 1989 Feb 15;45(2):146-8. doi: 10.1007/BF01954852.
6
Significance of the excretion of urinary indicator proteins for a low level of occupational exposure to cadmium.尿指示蛋白排泄对低水平职业性镉暴露的意义。
Int Arch Occup Environ Health. 1990;62(1):95-100. doi: 10.1007/BF00397855.

本文引用的文献

1
A radioimmunoassay for human metallothionein.一种针对人金属硫蛋白的放射免疫测定法。
Toxicol Appl Pharmacol. 1980 Aug;55(1):94-102. doi: 10.1016/0041-008x(80)90224-0.
2
Assessment of risk by biological monitoring.通过生物监测评估风险。
Br J Ind Med. 1981 May;38(2):198-201. doi: 10.1136/oem.38.2.198.
3
In vivo measurement of critical level of kidney cadmium: dose effect studies in cadmium smelter workers.体内肾脏镉临界水平的测量：镉冶炼工人的剂量效应研究。
Am J Ind Med. 1980;1(3-4):339-48. doi: 10.1002/ajim.4700010310.
4
Chronic cadmium exposures associated with kidney function effects.长期镉暴露与肾脏功能影响相关。
Am J Ind Med. 1980;1(3-4):319-37. doi: 10.1002/ajim.4700010309.
5
Elevated urinary excretion of metallothionein due to environmental cadmium exposure.环境镉暴露导致尿中金属硫蛋白排泄增加。
Toxicology. 1981;20(4):289-97. doi: 10.1016/0300-483x(81)90036-6.
6
Occupational cadmium exposure and renal status.
Am J Ind Med. 1983;4(4):541-9. doi: 10.1002/ajim.4700040408.
7
Cadmium-metallothionein-induced nephropathy.镉-金属硫蛋白诱导的肾病。
Toxicol Appl Pharmacol. 1976 Nov;38(2):399-408. doi: 10.1016/0041-008x(76)90146-0.
8
Radioimmunoassay of metallothioneins.金属硫蛋白的放射免疫测定法。
J Biol Chem. 1979 Sep 10;254(17):8416-21.
9
Production and study of antibody produced against rat cadmium thionein.
Immunochemistry. 1978 Dec;15(12):857-68. doi: 10.1016/0161-5890(78)90119-0.
10
Dose-response analysis of cadmium-induced tubular proteinuria: a study of urinary beta2-microglobulin excretion among workers in a battery factory.镉诱导肾小管蛋白尿的剂量反应分析：一项关于电池厂工人尿β2-微球蛋白排泄的研究
Environ Res. 1977 Apr;13(2):303-17. doi: 10.1016/0013-9351(77)90106-2.

金属硫蛋白与职业性镉暴露

Metallothionein and occupational exposure to cadmium.

作者信息

Falck F Y, Fine L J, Smith R G, Garvey J, Schork A, England B, McClatchey K D, Linton J

出版信息

Br J Ind Med. 1983 Aug;40(3):305-13. doi: 10.1136/oem.40.3.305.

DOI:10.1136/oem.40.3.305
PMID:6347245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1069327/
Abstract

The relationship between metallothionein (MT), chronic exposure to cadmium (Cd), and renal function was investigated in 53 men who were occupationally exposed to Cd. The aim was to determine if MT is a potential biological monitor for chronic exposure to Cd which would be useful for preventing Cd nephropathy. In this study MT excretion, serum MT, and serum creatinine concentrations were significantly higher in subjects with abnormal renal function who had been exposed to Cd. MT excretion was also linearly related on an individual basis to protein excretion, beta 2-microglobulin (beta 2-M) excretion, and cumulative time weighted exposure (dose). MT excretion was also a better predictor of dose than either beta 2-M excretion or Cd excretion. The findings suggest that MT is a potential biological monitor for chronic Cd exposure that would be useful for preventing Cd-induced nephropathy. Further studies of non-specific nephropathies and MT are needed to determine if MT is a specific indicator of proximal tubule function secondary to chronic exposure to Cd.

摘要

对53名职业性接触镉的男性，研究了金属硫蛋白（MT）、长期接触镉（Cd）与肾功能之间的关系。目的是确定MT是否为长期接触镉的潜在生物学监测指标，这对于预防镉肾病可能有用。在本研究中，肾功能异常且接触过镉的受试者的MT排泄、血清MT和血清肌酐浓度显著更高。MT排泄在个体水平上也与蛋白质排泄、β2-微球蛋白（β2-M）排泄以及累积时间加权暴露量（剂量）呈线性相关。与β2-M排泄或镉排泄相比，MT排泄也是更好的剂量预测指标。这些发现表明，MT是长期镉暴露的潜在生物学监测指标，对于预防镉诱导的肾病可能有用。需要对非特异性肾病和MT进行进一步研究，以确定MT是否为长期接触镉继发的近端小管功能的特异性指标。