癌症研究运动（国王学院/剑桥早期乳腺癌试验：临床病理方面）
The cancer research campaign (King's/Cambridge trial for early breast cancer: clinico-pathological aspects.
作者信息
Elston C W, Gresham G A, Rao G S, Zebro T, Haybittle J L, Houghton J, Kearney G
出版信息
Br J Cancer. 1982 May;45(5):655-69. doi: 10.1038/bjc.1982.106.
Abstract
Analysis of pathological data in the 10th year of follow-up of a multicentre trial of the management of operable breast cancer has confirmed the correlation of prognosis with tumour grade, tumour size and lymph-node status. For each factor examined there was no difference in survival between the 2 treatment groups ("watch policy" and radiotherapy) but patients in the WP group whose tumours were of Grade II or III or greater than 2 cm, or with lymph-node metastases, had a greater chance of local recurrence. Cellular reaction had no relationship with prognosis, except in patients with Grade III tumours. The clinical relevance and application of these results are discussed.
摘要
一项可手术乳腺癌治疗多中心试验随访10年的病理数据分析证实，预后与肿瘤分级、肿瘤大小及淋巴结状态相关。对于所研究的每个因素，两个治疗组（“观察策略”组和放疗组）的生存率无差异，但“观察策略”组中肿瘤为II级或III级、大于2厘米或有淋巴结转移的患者，局部复发几率更高。细胞反应与预后无关，III级肿瘤患者除外。本文讨论了这些结果的临床相关性及应用。
相似文献
1
The cancer research campaign (King's/Cambridge trial for early breast cancer: clinico-pathological aspects.癌症研究运动（国王学院/剑桥早期乳腺癌试验：临床病理方面）
Br J Cancer. 1982 May;45(5):655-69. doi: 10.1038/bjc.1982.106.
2
3
Evaluation of clinical parameters influencing the development of bone metastasis in breast cancer.影响乳腺癌骨转移发生的临床参数评估
BMC Cancer. 2016 May 12;16:307. doi: 10.1186/s12885-016-2345-7.
4
Biomarker expression and St Gallen molecular subtype classification in primary tumours, synchronous lymph node metastases and asynchronous relapses in primary breast cancer patients with 10 years' follow-up.在原发性乳腺癌患者中，进行了 10 年随访，检测了原发肿瘤、同期淋巴结转移和异时性复发中生物标志物的表达和圣加仑分子亚型分类。
Breast Cancer Res Treat. 2013 Jul;140(1):93-104. doi: 10.1007/s10549-013-2617-8. Epub 2013 Jun 27.
5
The Cancer Research Campaign (King's/Cambridge) trial for early breast cancer: an analysis of the radiotherapy data.
Br J Radiol. 1984 Apr;57(676):309-16. doi: 10.1259/0007-1285-57-676-309.
6
Influence of internal mammary node irradiation on long-term outcome and contralateral breast cancer incidence in node-negative breast cancer patients.内乳淋巴结照射对淋巴结阴性乳腺癌患者长期预后及对侧乳腺癌发生率的影响。
Radiother Oncol. 2013 Aug;108(2):259-65. doi: 10.1016/j.radonc.2013.06.028. Epub 2013 Jul 25.
7
Eight-year follow up result of the OTOASOR trial: The Optimal Treatment Of the Axilla - Surgery Or Radiotherapy after positive sentinel lymph node biopsy in early-stage breast cancer: A randomized, single centre, phase III, non-inferiority trial.OTOASOR试验的八年随访结果：早期乳腺癌前哨淋巴结活检阳性后腋窝的最佳治疗——手术或放疗：一项随机、单中心、III期、非劣效性试验。
Eur J Surg Oncol. 2017 Apr;43(4):672-679. doi: 10.1016/j.ejso.2016.12.011. Epub 2017 Jan 16.
8
[The effect of axillary lymph node status on the prognosis of patients with local-regional recurrence after breast-conserving surgery].[腋窝淋巴结状态对保乳手术后局部区域复发患者预后的影响]
Zhonghua Zhong Liu Za Zhi. 2018 May 23;40(5):347-351. doi: 10.3760/cma.j.issn.0253-3766.2018.05.006.
9
Pooled long-term outcomes from two randomized trials of axillary node sampling with axillary radiotherapy versus axillary node clearance in patients with operable node-positive breast cancer.两项随机临床试验的汇总长期结果显示，对于可手术阳性淋巴结乳腺癌患者，腋窝淋巴结采样联合腋窝放疗与腋窝淋巴结清扫相比。
Br J Surg. 2016 Jan;103(1):81-7. doi: 10.1002/bjs.9952.
10
[A new perspective on axillary dissection in situations of metastatic sentinel node].[转移性前哨淋巴结情况下腋窝清扫术的新视角]
Rozhl Chir. 2017 Fall;96(8):346-352.
引用本文的文献
1
Analysis of Spatial Distribution and Prognostic Value of Different Pan Cytokeratin Immunostaining Intensities in Breast Tumor Tissue Sections.分析乳腺肿瘤组织切片中不同全细胞角蛋白免疫染色强度的空间分布及预后价值。
Int J Mol Sci. 2020 Jun 22;21(12):4434. doi: 10.3390/ijms21124434.
2
Size and Shape Filtering of Malignant Cell Clusters within Breast Tumors Identifies Scattered Individual Epithelial Cells as the Most Valuable Histomorphological Clue in the Prognosis of Distant Metastasis Risk.乳腺肿瘤内恶性细胞簇的大小和形状过滤表明，散在的单个上皮细胞是远处转移风险预后中最有价值的组织形态学线索。
Cancers (Basel). 2019 Oct 22;11(10):1615. doi: 10.3390/cancers11101615.
3
Clinicopathological characteristics of infiltrating lobular breast carcinoma in elderly women: Preliminary results.老年女性浸润性小叶乳腺癌的临床病理特征：初步结果
Mol Clin Oncol. 2015 Nov;3(6):1337-1340. doi: 10.3892/mco.2015.625. Epub 2015 Aug 28.
4
Effect of specialized diagnostic assessment units on the time to diagnosis in screen-detected breast cancer patients.专业诊断评估单位对筛查发现的乳腺癌患者诊断时间的影响。
Br J Cancer. 2015 May 26;112(11):1744-50. doi: 10.1038/bjc.2015.147. Epub 2015 May 5.
5
Computer-based image studies on tumor nests mathematical features of breast cancer and their clinical prognostic value.基于计算机的图像研究对乳腺癌肿瘤巢的数学特征及其临床预后价值。
PLoS One. 2013 Dec 12;8(12):e82314. doi: 10.1371/journal.pone.0082314. eCollection 2013.
6
Genomic approaches in breast cancer research.基因组方法在乳腺癌研究中的应用。
Brief Funct Genomics. 2013 Sep;12(5):391-6. doi: 10.1093/bfgp/elt019. Epub 2013 Jun 20.
7
Interactions between immunity, proliferation and molecular subtype in breast cancer prognosis.免疫、增殖与分子亚型在乳腺癌预后中的相互作用。
Genome Biol. 2013 Apr 29;14(4):R34. doi: 10.1186/gb-2013-14-4-r34.
8
Statistical association of basal cell keratins with metastasis-inducing proteins in a prognostically unfavorable group of sporadic breast cancers.在一组预后不良的散发性乳腺癌中，基底细胞角蛋白与转移诱导蛋白的统计学关联。
Am J Pathol. 2011 Aug;179(2):1061-72. doi: 10.1016/j.ajpath.2011.04.022. Epub 2011 Jun 14.
9
Heterogeneity of invasive ductal carcinoma: proposal for a hypothetical classification.浸润性导管癌的异质性：一种假设性分类的提议。
J Korean Med Sci. 2006 Jun;21(3):460-8. doi: 10.3346/jkms.2006.21.3.460.
10
Morphometrical malignancy grading is a valuable prognostic factor in invasive ductal breast cancer.形态学恶性肿瘤分级是浸润性导管癌中一个有价值的预后因素。
Br J Cancer. 2002 Nov 18;87(11):1275-80. doi: 10.1038/sj.bjc.6600617.
本文引用的文献
1
Further studies on prognosis of breast carcinoma.乳腺癌预后的进一步研究。
Br J Cancer. 1950 Dec;4(4):347-67. doi: 10.1038/bjc.1950.34.
2
Prognosis in carcinoma of the breast.乳腺癌的预后
Br J Cancer. 1950 Sep;4(3):259-88. doi: 10.1038/bjc.1950.26.
3
Survival in breast cancer cases in relation to the structure of the primary tumor and regional lymph nodes.乳腺癌病例的生存情况与原发肿瘤及区域淋巴结结构的关系。
Surg Gynecol Obstet. 1955 May;100(5):543-51.
4
Inflammation and prognosis in breast cancer; a search for host resistance.乳腺癌中的炎症与预后；对宿主抵抗力的探索。
Cancer. 1959 Jul-Aug;12(4):714-20. doi: 10.1002/1097-0142(195907/08)12:4<714::aid-cncr2820120414>3.0.co;2-b.
5
Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years.乳腺癌的组织学分级与预后；对1409例病例的研究，其中359例已随访15年。
Br J Cancer. 1957 Sep;11(3):359-77. doi: 10.1038/bjc.1957.43.
6
Histological grading in carcinoma of the breast.乳腺癌的组织学分级
Br J Cancer. 1966 Mar;20(1):36-40. doi: 10.1038/bjc.1966.5.
7
Possible host resistance in carcinoma of the breast: a histological study.乳腺癌中可能存在的宿主抵抗力：一项组织学研究。
Br J Cancer. 1968 Sep;22(3):383-401. doi: 10.1038/bjc.1968.47.
8
Host resistance and survival in carcinoma of breast: a study of 104 cases of medullary carcinoma in a series of 1,411 cases of breast cancer followed for 20 years.乳腺癌患者的宿主抵抗力与生存率：对1411例乳腺癌患者中的104例髓样癌患者进行了为期20年的随访研究。
Br Med J. 1970 Jul 25;3(5716):181-8. doi: 10.1136/bmj.3.5716.181.
9
Cancer of the breast: size of neoplasm and prognosis.乳腺癌：肿瘤大小与预后
Cancer. 1969 Nov;24(5):1071-80. doi: 10.1002/1097-0142(196911)24:5<1071::aid-cncr2820240533>3.0.co;2-h.
10
Organization of clinical trial on national scale: management of early cancer of the breast.全国范围内的临床试验组织：早期乳腺癌的管理
Br Med J. 1972 Nov 25;4(5838):476-8. doi: 10.1136/bmj.4.5838.476.
Zotero 插件