Elston C W, Gresham G A, Rao G S, Zebro T, Haybittle J L, Houghton J, Kearney G
Br J Cancer. 1982 May;45(5):655-69. doi: 10.1038/bjc.1982.106.
Analysis of pathological data in the 10th year of follow-up of a multicentre trial of the management of operable breast cancer has confirmed the correlation of prognosis with tumour grade, tumour size and lymph-node status. For each factor examined there was no difference in survival between the 2 treatment groups ("watch policy" and radiotherapy) but patients in the WP group whose tumours were of Grade II or III or greater than 2 cm, or with lymph-node metastases, had a greater chance of local recurrence. Cellular reaction had no relationship with prognosis, except in patients with Grade III tumours. The clinical relevance and application of these results are discussed.
一项可手术乳腺癌治疗多中心试验随访10年的病理数据分析证实，预后与肿瘤分级、肿瘤大小及淋巴结状态相关。对于所研究的每个因素，两个治疗组（“观察策略”组和放疗组）的生存率无差异，但“观察策略”组中肿瘤为II级或III级、大于2厘米或有淋巴结转移的患者，局部复发几率更高。细胞反应与预后无关，III级肿瘤患者除外。本文讨论了这些结果的临床相关性及应用。
