Lutz J, Barthel U, Metzenauer P
Circ Shock. 1982;9(2):99-106.
Treatment with perfluorochemicals (PFCs) shows a temporary decrease in phagocytic activity as measured by carbon clearance. The importance of this effect was checked by investigating the lethality after administrations of PFCs and Escherichia coli endotoxin in mice (NMRI strain). When endotoxin was applied simultaneously with PFC (4.4 g/kg body weight, a dose which could compensate a loss of a third of blood volume) the lethality rose 7.8-fold. If the challenge with endotoxin occurred later than 12 h after PFC injection, the increase of lethality was of a distinctly smaller degree. By means of pretreatment with various substances the increased lethality of endotoxin could be shifted in the direction of the control. C 48/80, aristolochic acid, and hydrocortisone were effective in this respect; zymosan remained ineffective. The results show a weakened resistance towards toxins from the intestinal tract under PFC administration; precaution in this regard should be taken during therapy with PFC.
用全氟化合物（PFCs）进行治疗时，通过碳清除率测定可发现吞噬活性出现暂时下降。通过研究给小鼠（NMRI品系）注射PFCs和大肠杆菌内毒素后的致死率，检验了这种效应的重要性。当内毒素与PFC（4.4克/千克体重，该剂量可补偿三分之一血容量的损失）同时应用时，致死率上升了7.8倍。如果在内毒素攻击发生于PFC注射12小时之后，则致死率的增加程度明显较小。通过用各种物质进行预处理，内毒素增加的致死率可朝着对照方向转变。在这方面，C 48/80、马兜铃酸和氢化可的松有效；酵母聚糖则无效。结果表明，在给予PFC期间，对来自肠道毒素的抵抗力减弱；在PFC治疗期间应在这方面加以注意。
