Jones R W
Eur J Rheumatol Inflamm. 1982;5(2):216-23.
Benoxaprofen is a nonsteroidal anti-inflammatory agent with a novel spectrum of pharmacological activity including regulatory effects on monocytes. It significantly reduces the serum alkaline phosphatase in patients with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The reduction usually has been within the normal range, but sometimes there has been a change from an abnormal to a normal value. The possible significance of this observation and ways of examining it further are discussed in this review. The reduction may be an effect on osteoblasts secondary to an effect on osteoclasts, cells known to be derived from monocyte precursors. If so, benoxaprofen should be effective in Paget's disease of the bone and preliminary data suggest this may be so.
苯恶洛芬是一种具有新型药理活性谱的非甾体抗炎药，包括对单核细胞的调节作用。它能显著降低骨关节炎、类风湿性关节炎和强直性脊柱炎患者的血清碱性磷酸酶。这种降低通常在正常范围内，但有时会从异常值变为正常。本综述讨论了这一观察结果的可能意义以及进一步研究的方法。这种降低可能是对破骨细胞产生影响后对成骨细胞的继发作用，已知破骨细胞来源于单核细胞前体。如果是这样，苯恶洛芬在骨Paget病中应该有效，初步数据表明可能如此。
