Dunagan F M, McGill P E, Kelman A W, Whiting B
Br J Clin Pharmacol. 1986 Apr;21(4):409-16. doi: 10.1111/j.1365-2125.1986.tb05215.x.
Response to non-steroidal anti-inflammatory drugs (NSAIDs) is not usually assessed on the basis of concentration measurements: identification of a concentration-effect relationship has proved difficult to achieve. Dose and concentration-effect relationships of fenclofenac have been determined in a group of 18 patients with rheumatoid arthritis at three dose levels (600, 1200 and 1800 mg day-1). The study was double-blind and treatments were randomised according to a Latin square design. A multiple linear regression technique (GLIM) was used in the analysis. The best model to describe the change in effect in terms of dose and concentration incorporated an average slope and an individual subject intercept for each effect measurement. On average, an improvement in grip strength of 20 mm Hg could be obtained with an increase in fenclofenac (trough) concentration of 100 micrograms ml-1.
通常不会基于浓度测量来评估对非甾体抗炎药（NSAIDs）的反应：已证明难以确定浓度-效应关系。在一组18名类风湿性关节炎患者中，于三个剂量水平（600、1200和1800毫克/天）测定了双氯芬酸的剂量和浓度-效应关系。该研究为双盲研究，治疗根据拉丁方设计进行随机分组。分析中使用了多元线性回归技术（GLIM）。用于描述剂量和浓度效应变化的最佳模型，对于每个效应测量值都纳入了平均斜率和个体受试者截距。平均而言，双氯芬酸（谷值）浓度每增加100微克/毫升，握力可提高20毫米汞柱。
