Lebenthal E, Lee P C
Digestion. 1982;23(1):39-47. doi: 10.1159/000198708.
Duodenal fluids from control and cystic fibrosis (CF) patients were assayed for enterokinase (EK), trypsin and chymotrypsin activities. CF patients as a group were found to have higher basal EK activity in spite of low trypsin and chymotrypsin activities. In control patients, pancreozymin (CCK) injection led to increases in specific activities of trypsin and chymotrypsin and a decrease in EK but did not change the total EK activities. Secretin administration led to decreases in specific activities of trypsin and chymotrypsin compared to post-CCK levels. The total EK activities were greatly increased following secretin administration. Thus, secretin may have direct influence on the release of EK into the duodenum. CCK and secretin have no effect on the specific activities of trypsin, chymotrypsin and EK in CF patients. EK release in CF patients is either constitutive and therefore not affected by CCK and secretin or it has been fully induced by the low trypsin content and becomes unresponsive to further hormonal stimulation.
对对照组和囊性纤维化（CF）患者的十二指肠液进行了肠激酶（EK）、胰蛋白酶和糜蛋白酶活性检测。尽管CF患者的胰蛋白酶和糜蛋白酶活性较低，但作为一个群体，他们的基础EK活性较高。在对照组患者中，注射胰酶泌素（CCK）会导致胰蛋白酶和糜蛋白酶的比活性增加，EK减少，但总EK活性不变。与注射CCK后的水平相比，注射促胰液素会导致胰蛋白酶和糜蛋白酶的比活性降低。注射促胰液素后，总EK活性大幅增加。因此，促胰液素可能对EK释放到十二指肠有直接影响。CCK和促胰液素对CF患者的胰蛋白酶、糜蛋白酶和EK的比活性没有影响。CF患者中EK的释放要么是组成性的，因此不受CCK和促胰液素的影响，要么是由于胰蛋白酶含量低而被完全诱导，对进一步的激素刺激不再有反应。
