Kapadia S B, Dekker A, Cheng V S, Desai U, Watson C G
Head Neck Surg. 1982 Mar-Apr;4(4):270-80. doi: 10.1002/hed.2890040403.
This study reviews 21 cases of thyroid lymphoma diagnosed between 1969 and 1980. The thyroid gland was the primary site in all but two cases. The 20 patients with non-Hodgkin lymphoma had a mean age of 66 years, 75% were women, and all were Caucasian. A rapidly growing thyroid mass with hoarseness, dysphagia, and difficulty in breathing was the initial finding. Most patients had diffuse histiocytic lymphomas. Associated Hashimoto thyroiditis was found histologically in 57% of the cases. Using the immunoperoxidase stain method on tissue sections, intracytoplasmic monoclonal immunoglobulin was demonstrated in 5 of 15 cases. All but two patients received radiation therapy, and 13 received chemotherapy. The median survival was 8 months; 20% died of unrelated causes and 32% are alive (average duration: 27 months). Dissemination, after local control by radiation therapy, was the leading cause of death. The prognosis was better in men, in patients under the age of 65 years, and in those patients who, on biopsy, did not have involvement of the extrathyroid soft tissue or regional lymph nodes.
本研究回顾了1969年至1980年间诊断的21例甲状腺淋巴瘤病例。除两例外，甲状腺均为原发部位。20例非霍奇金淋巴瘤患者的平均年龄为66岁，75%为女性，均为白种人。最初的表现为甲状腺肿块迅速增大，并伴有声音嘶哑、吞咽困难和呼吸困难。大多数患者为弥漫性组织细胞淋巴瘤。组织学检查发现57%的病例伴有桥本甲状腺炎。在15例病例中的5例中，采用免疫过氧化物酶染色法在组织切片上证实了胞浆内单克隆免疫球蛋白的存在。除两名患者外，所有患者均接受了放射治疗，13例接受了化疗。中位生存期为8个月；20%死于无关原因，32%存活（平均病程：27个月）。放射治疗局部控制后发生播散是主要死因。男性、65岁以下患者以及活检时甲状腺外软组织或区域淋巴结未受累的患者预后较好。
