Bolte H D, Schultheiss P
Postgrad Med J. 1978 Jul;54(633):500-4. doi: 10.1136/pgmj.54.633.500.
Immunological studies have shown new diagnostically important changes in alcoholic and viral myocarditis, as well as in congestive cardiomyopathy. Increased heart size correlated with the degree of congestive heart failure, as well as with negative immunofluorescence and an increased IgA concentration in the serum. These findings may serve as a diagnostic aid in patients with myocardial disease due to alcohol abuse. Viral heart disease is characterized by a variety of symptoms and nuclear antibodies (IgM) can be of help in the differential diagnosis. Heart muscle tissue of patients with congestive cardiomyopathy preferentially binds IgG and IgA. In addition to the other changes these findings are of diagnostic importance. It seems likely that results similar to those obtained for humoral antibodies in congestive cardiomyopathy will apply in the correlation of the haemodynamic status of the patients. The pathophysiological implication of these findings is not clear at present, but the evolution of congestive cardiomyopathy appears to be associated with binding of immunoglobulin to the myocardium, as well as with humoral antiheart antibodies.
免疫学研究表明，酒精性和病毒性心肌炎以及充血性心肌病出现了具有新的诊断意义的变化。心脏增大与充血性心力衰竭的程度相关，也与免疫荧光阴性和血清中IgA浓度升高相关。这些发现可能有助于诊断因酒精滥用导致的心肌疾病患者。病毒性心脏病具有多种症状，核抗体（IgM）有助于鉴别诊断。充血性心肌病患者的心肌组织优先结合IgG和IgA。除其他变化外，这些发现具有诊断意义。充血性心肌病患者中与体液抗体相关的结果似乎也适用于患者血流动力学状态的相关性。目前这些发现的病理生理意义尚不清楚，但充血性心肌病的发展似乎与免疫球蛋白与心肌的结合以及体液抗心脏抗体有关。
