Flint D J
J Endocrinol. 1982 May;93(2):279-85. doi: 10.1677/joe.0.0930279.
Bromocriptine treatment of lactating rats, or removal of the litter, led to a decrease in the number of insulin receptors in the mammary gland and an increase in the concentration of insulin in the serum. Bromocriptine also induced a decrease in the concentration of both prolactin and progesterone in the serum, whilst concurrent treatment with the former but not the latter prevented all the effects of bromocriptine for 48 h. Removal of the litter produced a similar decrease in the concentration in the serum of prolactin but not of progesterone. Treatment with prolactin prevented all of the effects of removal of the litter for 24 but not 48 h. This suggests that these effects of prolactin may require a mammary gland actually synthesizing milk since the gland rapidly fills with milk after removing the litter whereas milk removal continues to take place in bromocriptine-treated rats allowed to continue nursing their litters.
用溴隐亭治疗哺乳期大鼠，或移除幼崽，会导致乳腺中胰岛素受体数量减少，血清中胰岛素浓度升高。溴隐亭还会使血清中催乳素和孕酮的浓度降低，而同时使用前者而非后者可在48小时内预防溴隐亭的所有作用。移除幼崽会使血清中催乳素浓度出现类似下降，但孕酮浓度未下降。用催乳素治疗可在24小时而非48小时内预防移除幼崽的所有作用。这表明催乳素的这些作用可能需要乳腺实际合成乳汁，因为移除幼崽后乳腺会迅速充满乳汁，而在允许继续哺育幼崽的溴隐亭治疗大鼠中，乳汁仍会持续排出。
