Martins R N, Stokes G B
Department of Biochemistry, University of Western Australia, Nedlands.
Mol Cell Biochem. 1987 Aug;76(2):133-40. doi: 10.1007/BF00223478.
The activities of the hexose monophosphate dehydrogenases increased in adipose tissue, remained unchanged in liver and decreased in mammary gland following the weaning of rats at mid-lactation (day 14). When dietary intake was restricted at mid-lactation, the activities of the hexose monophosphate dehydrogenases increased in adipose tissue, decreased in liver, but were unaltered in mammary gland. Premature weaning on day 14 postpartum resulted in maternal increases in both plasma insulin and glucose, which peaked at day 16. The plasma insulin levels decreased from day 14 to day 18 postpartum in the normal lactating rat, and a similar trend was observed for animals on a restricted dietary intake. Daily food consumption in the lactating rat decreased from 50 g to 20 g after premature weaning. The live weight of pups raised on dams given a restricted food intake from day 14 had decreased by day 17 postpartum, whereas an increase in daily live weight gain was recorded for the litters from the lactating controls. The results demonstrate that the activities of the hexose monophosphate dehydrogenases are regulated differentially between tissues of the lactating rat.
在泌乳中期（第14天）对大鼠进行断奶后，脂肪组织中己糖磷酸脱氢酶的活性增加，肝脏中该酶活性保持不变，而乳腺中该酶活性降低。当在泌乳中期限制饮食摄入时，脂肪组织中己糖磷酸脱氢酶的活性增加，肝脏中该酶活性降低，而乳腺中该酶活性未发生改变。产后第14天提前断奶导致母体血浆胰岛素和葡萄糖水平升高，在第16天达到峰值。正常泌乳大鼠产后第14天至第18天血浆胰岛素水平下降，饮食摄入受限的动物也观察到类似趋势。提前断奶后，泌乳大鼠的每日食物消耗量从50克降至20克。从第14天起给母鼠提供受限食物摄入量，所哺育幼崽的体重在产后第17天有所下降，而泌乳对照组所产幼崽的日体重增加量则有所记录。结果表明，泌乳大鼠不同组织中己糖磷酸脱氢酶的活性受到不同调节。
