Bailey A J, Sloane J P, Trickey B S, Ormerod M G
J Pathol. 1982 May;137(1):13-23. doi: 10.1002/path.1711370103.
The distribution of the milk protein, lactalbumin, has been studied in human breast tissue by the indirect immunoperoxidase technique on formalin fixed paraffin embedded sections. It was found in all lactating breasts examined and in all breasts from subjects who were more than 18 weeks pregnant. It was also seen in a small proportion of non-pregnant, non-lactating patients usually confined to small focal secretory lobular lesions known as lactational foci but also occasionally in morphologically normal lobules. Previous pregnancy does not appear to be a pre-requisite for lactalbumin secretion and our study suggests a possible relationship with usage of hormonal preparations. A wide variety of benign and malignant breast lesions were studied and none was found to contain the protein, except for fibroadenomas from patients who were pregnant or who harboured lactional foci. The absence of lactalbumin from all 44 breast carcinomas studied suggests that it has no role to play as a marker in the histopathological diagnosis or clinical monitoring of this disease.
运用间接免疫过氧化物酶技术，在福尔马林固定、石蜡包埋的切片上，对人乳腺组织中的乳蛋白——乳白蛋白的分布情况进行了研究。在所检查的所有泌乳乳腺以及所有怀孕超过18周的受试者的乳腺中均发现了乳白蛋白。在一小部分非妊娠、非泌乳患者中也可见到乳白蛋白，通常局限于称为泌乳灶的小灶性分泌性小叶病变，但偶尔也见于形态正常的小叶中。既往妊娠似乎并非乳白蛋白分泌的先决条件，我们的研究提示其可能与激素制剂的使用有关。对多种良性和恶性乳腺病变进行了研究，除了来自怀孕患者或有泌乳灶的患者的纤维腺瘤外，未发现其他病变含有该蛋白。在所研究的44例乳腺癌中均未发现乳白蛋白，这表明它在该疾病的组织病理学诊断或临床监测中没有作为标志物的作用。
