Oduola A M, Holbrook T W, Galbraith R M, Bank H, Spicer S S
J Protozool. 1982 Feb;29(1):77-81. doi: 10.1111/j.1550-7408.1982.tb02883.x.
Plasmodium berghei infection was more severe in pregnant than in nonpregnant mice. Infection initiated on gestation day 7 resulted in rapidly increasing parasitemia and deaths of all pregnant mice within 12 days, while some nonpregnant mice survived until day 21 postinfection. When mice were infected on gestation day 12 or 14, a proportion of mice died before parturition; but some animals survived to deliver living pups. Reduced birthweights and increased spleen weight to body weight ratios were seen in pups from infected mice as compared with pups from uninfected animals. Histopathological abnormalities of placentae from infected animals included degeneration of the normal labyrinthine architecture and thickening of the trophoblast separating maternal and fetal blood vessels.
伯氏疟原虫感染在怀孕小鼠中比未怀孕小鼠更为严重。在妊娠第7天开始感染，导致所有怀孕小鼠的疟原虫血症迅速增加，并在12天内死亡，而一些未怀孕小鼠存活至感染后第21天。当小鼠在妊娠第12天或第14天感染时，一部分小鼠在分娩前死亡；但一些动物存活下来并产下活仔。与未感染动物的幼崽相比，感染小鼠的幼崽出生体重降低，脾重与体重之比增加。感染动物胎盘的组织病理学异常包括正常迷路结构的退化以及分隔母血和胎儿血管的滋养层增厚。
