Yam D, Zilberstein A, Fink A, Nir I
Weizmann Institute of Science, Rehovot, Israel.
Br J Cancer. 1990 May;61(5):689-94. doi: 10.1038/bjc.1990.156.
A study has been carried out in which a comparison was made between EL4 lymphoma (assumed to be an insulin-producing secreting tumour) and thymoma (an insulin-dependent tumour). Tumour development and incidence, 3H-thymidine incorporation and insulin content in tumours, the host's food intake, blood insulin, glucose and cholesterol were determined in non-diabetic and alloxan-diabetic mice. Whereas no significant differences were observed between the diabetic and non-diabetic EL4 tumour-bearing mice, the diabetic, thymoma tumour-bearing mice showed reduced tumour growth and lower tumour incidence as compared with their non-diabetic counterparts. Insulin administration to diabetic tumour bearing mice, enhanced 3H-thymidine incorporation in the thymoma tumour cells only, and the insulin content of the EL4 tumours was found to be higher than that of the thymoma tumours. Rapid diabetes remission was observed in the diabetic, EL4 tumour-bearing mice as compared with the thymoma tumour-bearing mice.
已开展一项研究，对EL4淋巴瘤（假定为产生胰岛素的分泌性肿瘤）和胸腺瘤（胰岛素依赖性肿瘤）进行了比较。在非糖尿病和四氧嘧啶糖尿病小鼠中，测定了肿瘤的发生发展及发病率、肿瘤中3H-胸腺嘧啶核苷掺入情况和胰岛素含量、宿主的食物摄入量、血液胰岛素、葡萄糖和胆固醇。虽然在糖尿病和非糖尿病的荷EL4肿瘤小鼠之间未观察到显著差异，但与非糖尿病的荷胸腺瘤小鼠相比，糖尿病的荷胸腺瘤小鼠肿瘤生长减缓且肿瘤发病率较低。对糖尿病的荷瘤小鼠注射胰岛素，仅增强了胸腺瘤肿瘤细胞中的3H-胸腺嘧啶核苷掺入，且发现EL4肿瘤的胰岛素含量高于胸腺瘤肿瘤。与荷胸腺瘤小鼠相比，在糖尿病的荷EL4肿瘤小鼠中观察到糖尿病快速缓解。
