Blohmé I, Johansson S
Kidney Int. 1981 Nov;20(5):671-5. doi: 10.1038/ki.1981.192.
In a series of 772 renal transplant patients, 84 had analgesic nephropathy (AN). Four of them had renal pelvic carcinoma. The incidence of atypical urothelial changes of the renal pelvis was studied in 56 AN patients, the majority nephrectomized before or shortly after the renal transplantation. Urothelial atypia, usually bilaterally, was found in 27 patients. Multiple sections resulted in an even higher incidence (8/9). No atypical changes were found in normal kidneys or in end-stage diseased kidneys with other diseases, or in chronically rejected renal allografts. These findings further strengthen the association between intake of phenacetin-containing analgesics and the development of renal pelvic tumors. Patients with end-stage analgesic nephropathy are a high-risk group for developing urinary tract tumors and should be subjected to endoscopic and cytologic surveillance. After renal transplantation, prophylactic bilateral nephroureterectomy is advocated.
在一组772例肾移植患者中，84例患有镇痛剂肾病（AN）。其中4例发生肾盂癌。对56例AN患者的肾盂非典型尿路上皮改变发生率进行了研究，大多数患者在肾移植前或肾移植后不久接受了肾切除术。27例患者发现尿路上皮异型性，通常为双侧性。多切片检查导致更高的发生率（8/9）。在正常肾脏、患有其他疾病的终末期患病肾脏或慢性排斥的同种异体肾移植中未发现非典型改变。这些发现进一步加强了含非那西丁镇痛剂的摄入与肾盂肿瘤发生之间的关联。终末期镇痛剂肾病患者是发生尿路肿瘤的高危人群，应接受内镜和细胞学监测。肾移植后，主张进行预防性双侧肾输尿管切除术。
