Vunder P A, Ivanova I I, Lapshina V F, Anishchenko T G
Probl Endokrinol (Mosk). 1978 Sep-Oct;24(5):66-70.
Administration of phentholamine or obsidan to rats for 3 weeks sharply diminished the diabetogenic action of alloxan. The insular tissue of the pancreas became less affected, and the percentage of animals with signs of diabetes (polyuria, glucosuria, and hyperglycemia) decreased. Hyperglycemia (averaging 276 and 286 mg%) was revealed in the majority of the animals given alloxan and adrenoblockers. Phentholamine sharply suppressed the development of polyuria in rats with intact pancreas following water load, but obsidan produced no such effect. The mechanism of action of adrenoblockers used on polyuria and glucosuria in animals given alloxan is suggested on the basis of experiments with water load.
给大鼠连续3周注射酚妥拉明或奥昔坦，可显著降低四氧嘧啶的致糖尿病作用。胰腺的胰岛组织受影响程度减轻，出现糖尿病症状（多尿、糖尿和高血糖）的动物百分比降低。大多数注射四氧嘧啶和肾上腺阻滞剂的动物出现了高血糖（平均为276和286毫克%）。酚妥拉明能显著抑制水负荷后胰腺完整大鼠的多尿发展，但奥昔坦无此作用。基于水负荷实验，推测了肾上腺阻滞剂对注射四氧嘧啶动物的多尿和糖尿的作用机制。
