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硬膜外吗啡用于术后疼痛治疗(作者译)

[Peridural morphine in the treatment of postoperative pain (author's transl)].

作者信息

Mihic D N, Binkert E, Hess F A, Orucevic J, Turner J

出版信息

Reg Anaesth. 1982 Apr;5(2):42-6.

PMID:7045987
Abstract

The action of peridural morphine (1.5, 3.0 and 5.0 mg) as compared to placebo was studied in the patients who underwent inguinal hernia repair or lower extremity surgery under peridural anaesthesia. Morphine produced a dose-dependent intensive and long lasting segmental analgesia which was statistically significantly superior to placebo at all dosages. This action was however accompanied by a high incidence of urine retention and vomiting. We did not find any respiratory or circulatory depression. Nevertheless, it is accentuated that under different clinical conditions this depression might be highly probable.

摘要

在接受硬膜外麻醉下行腹股沟疝修补术或下肢手术的患者中,研究了硬膜外注射吗啡(1.5毫克、3.0毫克和5.0毫克)与安慰剂相比的作用。吗啡产生剂量依赖性的强烈且持久的节段性镇痛作用,在所有剂量下,该作用在统计学上均显著优于安慰剂。然而,这一作用伴随着高发生率的尿潴留和呕吐。我们未发现任何呼吸或循环抑制情况。尽管如此,需要强调的是,在不同的临床条件下,这种抑制很可能会出现。

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