Pazdur J, Winney C, Baum J
J Clin Lab Immunol. 1982 Apr;7(3):179-85.
The production of a lymphokine, polymorphonuclear leukocyte (PMN) chemotactic factor (CF) was studied in lymphocytes obtained from patients with rheumatoid-factor positive rheumatoid arthritis (RA). Control lymphocytes and PMN were obtained from normal individuals. The stimulation of the lymphocytes was by phytohemagglutinin (PHA) and by mixed leukocyte culture. CF was produced to the same degree by the cells from normals and from patients with RA by either type of stimulation. There is significantly less 3H-Thymidine uptake in cells from RA patients as measured by counts per minute although the stimulation index was the same. This can be accounted for by decreased proliferation of RA cells.
对类风湿因子阳性的类风湿性关节炎（RA）患者淋巴细胞中淋巴因子——多形核白细胞（PMN）趋化因子（CF）的产生进行了研究。对照淋巴细胞和PMN取自正常个体。淋巴细胞通过植物血凝素（PHA）和混合白细胞培养进行刺激。无论是哪种刺激方式，正常人和RA患者的细胞产生CF的程度相同。尽管刺激指数相同，但通过每分钟计数测量，RA患者细胞中3H-胸腺嘧啶核苷的摄取明显较少。这可以通过RA细胞增殖减少来解释。
