Marie J P, Escribano L, Perrot J Y, Boucheix C, Kayibanda M, Martyre M C, Cadiou M, Rosenfeld C, Zittoun R
Nouv Presse Med. 1982 May 8;11(21):1603-6.
In a retrospective study of 112 adult patients with acute leukaemia (AL), the percentage of undifferentiated leukaemia was reduced to almost 1% by an analysis of routine cytochemical reactions (PAS, peroxidase, esterases and esterase inhibition), B and T lymphocyte markers (IgS, E-rosettes, HuTLA) cAll antigen and ultrastructural detection of peroxidase activity (PO-ME). A simultaneous study of cALL antigen and PO-ME showed reciprocal exclusion of these markers, except in one case of mixed leukaemia. Therapeutically, the value of these tests lies in that patients with typical PAS reaction and cALL antigen consistently respond to vincristine- corticosteroid treatment, whereas patients without cALL and with PO-ME are frequently resistant to that combination of drugs.
在一项对112例成年急性白血病（AL）患者的回顾性研究中，通过对常规细胞化学反应（PAS、过氧化物酶、酯酶和酯酶抑制）、B和T淋巴细胞标志物（IgS、E花环、HuTLA）、cALL抗原以及过氧化物酶活性的超微结构检测（PO-ME）分析，未分化白血病的比例降至近1%。对cALL抗原和PO-ME的同步研究显示，除1例混合性白血病外，这些标志物相互排斥。在治疗方面，这些检测的价值在于，具有典型PAS反应和cALL抗原的患者对长春新碱-皮质类固醇治疗始终有反应，而没有cALL且有PO-ME的患者通常对该药物组合耐药。
