• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities.胰岛素作用的潜在介质：丙酮酸脱氢酶和腺苷酸环化酶活性的调节
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3513-7. doi: 10.1073/pnas.79.11.3513.
2
Insulin mediator causes dephosphorylation of the alpha subunit of pyruvate dehydrogenase by stimulating phosphatase activity.胰岛素介质通过刺激磷酸酶活性导致丙酮酸脱氢酶α亚基去磷酸化。
Arch Biochem Biophys. 1985 Feb 15;237(1):142-50. doi: 10.1016/0003-9861(85)90263-2.
3
Putative mediators of insulin action regulate hepatic acetyl CoA carboxylase activity.胰岛素作用的假定介质调节肝脏乙酰辅酶A羧化酶活性。
Biochem Biophys Res Commun. 1983 Feb 10;110(3):789-95. doi: 10.1016/0006-291x(83)91031-8.
4
Action of feedback regulator on adenylate cyclase.反馈调节因子对腺苷酸环化酶的作用。
Proc Natl Acad Sci U S A. 1975 May;72(5):1773-7. doi: 10.1073/pnas.72.5.1773.
5
Effect of S-adenosylhomocysteine on insulin-independent release of pyruvate dehydrogenase activator from rat adipocyte plasma membranes.S-腺苷同型半胱氨酸对大鼠脂肪细胞质膜丙酮酸脱氢酶激活剂非胰岛素依赖性释放的影响。
Biochem Biophys Res Commun. 1987 Mar 30;143(3):832-6. doi: 10.1016/0006-291x(87)90324-x.
6
Insulin stimulates generation of intracellular mediators in rat heart.胰岛素刺激大鼠心脏中细胞内介质的生成。
Arch Biochem Biophys. 1985 Sep;241(2):432-7. doi: 10.1016/0003-9861(85)90567-3.
7
Insulin-like effects of ATP on adipocyte pyruvate dehydrogenase and phosphorylase.ATP对脂肪细胞丙酮酸脱氢酶和磷酸化酶的类胰岛素效应。
Arch Biochem Biophys. 1990 Jan;276(1):232-5. doi: 10.1016/0003-9861(90)90031-s.
8
Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: evidence for generated of insulin's second messenger in a subcellular system.通过直接向分离的质膜/线粒体混合物中添加胰岛素来激活丙酮酸脱氢酶：亚细胞系统中胰岛素第二信使生成的证据。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):77-81. doi: 10.1073/pnas.77.1.77.
9
Insulin and vasopressin elicit inhibition of cholera-toxin-stimulated adenylate cyclase activity in both hepatocytes and the P9 immortalized hepatocyte cell line through an action involving protein kinase C.胰岛素和血管加压素通过涉及蛋白激酶C的作用，对霍乱毒素刺激的肝细胞和P9永生化肝细胞系中的腺苷酸环化酶活性产生抑制作用。
Biochem J. 1995 Dec 15;312 ( Pt 3)(Pt 3):769-74. doi: 10.1042/bj3120769.
10
Persistence of the effect of insulin on pyruvate dehydrogenase activity in rat white and brown adipose tissue during the preparation and subsequent incubation of mitochondria.在制备大鼠白色和棕色脂肪组织线粒体及随后的孵育过程中，胰岛素对丙酮酸脱氢酶活性的影响持续存在。
Biochem J. 1984 Jan 15;217(2):441-52. doi: 10.1042/bj2170441.

引用本文的文献

1
The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases.肌醇的生物医学用途：一种针对衰老和神经退行性疾病中代谢功能障碍的营养补充剂方法。
Biomedicines. 2020 Aug 20;8(9):295. doi: 10.3390/biomedicines8090295.
2
Structure and function of the insulin receptor-a personal perspective.胰岛素受体的结构与功能：个人观点。
Proc Jpn Acad Ser B Phys Biol Sci. 2019;95(10):581-589. doi: 10.2183/pjab.95.039.
3
Derangements of pyruvate dehydrogenase in circulating lymphocytes of NIDDM patients and their healthy offspring.非胰岛素依赖型糖尿病患者及其健康后代循环淋巴细胞中丙酮酸脱氢酶的紊乱
J Endocrinol Invest. 1999 Jul-Aug;22(7):519-26. doi: 10.1007/BF03343603.
4
Molecular effects of sulphonylurea agents in circulating lymphocytes of patients with non-insulin-dependent diabetes mellitus.磺酰脲类药物对非胰岛素依赖型糖尿病患者循环淋巴细胞的分子效应。
Br J Clin Pharmacol. 1998 Mar;45(3):291-9. doi: 10.1046/j.1365-2125.1998.00680.x.
5
chiro-inositol deficiency and insulin resistance: a comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects.手性肌醇缺乏与胰岛素抵抗：从对照和II型糖尿病受试者的尿液、血液透析液及肌肉中分离出的含手性肌醇和含肌醇的胰岛素介质的比较
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):5924-8. doi: 10.1073/pnas.90.13.5924.
6
Mechanisms of the fasting-induced dissociation of insulin binding from its action in isolated rat hepatocytes.禁食诱导胰岛素结合与其在分离的大鼠肝细胞中的作用解离的机制。
Mol Cell Biochem. 1984 Apr;62(1):25-36. doi: 10.1007/BF00230074.
7
Effects of theophylline on insulin receptors and insulin action in the adipocyte.茶碱对脂肪细胞中胰岛素受体及胰岛素作用的影响。
Mol Cell Biochem. 1983;57(2):177-83. doi: 10.1007/BF00849194.
8
Persistence of the effect of insulin on pyruvate dehydrogenase activity in rat white and brown adipose tissue during the preparation and subsequent incubation of mitochondria.在制备大鼠白色和棕色脂肪组织线粒体及随后的孵育过程中，胰岛素对丙酮酸脱氢酶活性的影响持续存在。
Biochem J. 1984 Jan 15;217(2):441-52. doi: 10.1042/bj2170441.
9
Inhibition of insulin receptor phosphorylation by indomethacin.吲哚美辛对胰岛素受体磷酸化的抑制作用。
Mol Cell Biochem. 1985 Nov;69(1):83-91. doi: 10.1007/BF00225930.
10
Participation of cellular thiol/disulphide groups in the uptake, degradation and bioactivity of insulin in primary cultures of rat hepatocytes.细胞硫醇/二硫键基团在大鼠肝细胞原代培养物中胰岛素的摄取、降解及生物活性中的作用。
Biochem J. 1985 Jan 15;225(2):349-56. doi: 10.1042/bj2250349.

本文引用的文献

1
METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS.分离脂肪细胞的代谢。I. 激素对葡萄糖代谢和脂肪分解的影响。
J Biol Chem. 1964 Feb;239:375-80.
2
Insulin action on the adenyl cyclase system: Antagonism to activation by lipolytic hormones.胰岛素对腺苷酸环化酶系统的作用：对脂解激素激活作用的拮抗。
FEBS Lett. 1972 Feb 1;20(2):191-194. doi: 10.1016/0014-5793(72)80791-9.
3
Insulin stimulates the release from liver plasma membranes of a chemical modulator of pyruvate dehydrogenase.胰岛素刺激丙酮酸脱氢酶的一种化学调节剂从肝细胞膜释放。
Biochem Biophys Res Commun. 1981 Oct 15;102(3):1041-7. doi: 10.1016/0006-291x(81)91643-0.
4
Partial purification from rat adipocyte plasma membranes of a chemical mediator which simulates the action of insulin on pyruvate dehydrogenase.从大鼠脂肪细胞质膜中部分纯化出一种化学介质，该介质可模拟胰岛素对丙酮酸脱氢酶的作用。
J Biol Chem. 1981 Mar 25;256(6):2945-51.
5
Characterization of a pyruvate dehydrogenase activator released by adipocyte plasma membranes in response to insulin.脂肪细胞质膜响应胰岛素释放的丙酮酸脱氢酶激活剂的特性分析。
J Biol Chem. 1981 Mar 25;256(6):2894-9.
6
Insulin action.胰岛素作用
Am J Med. 1981 Jan;70(1):142-50. doi: 10.1016/0002-9343(81)90421-6.
7
Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator.有证据表明胰岛素在生成次级化学介质时会激活一种内在质膜蛋白酶。
J Biol Chem. 1980 Jul 25;255(14):6529-31.
8
Activation of pyruvate dehydrogenase by direct addition of insulin to an isolated plasma membrane/mitochondria mixture: evidence for generated of insulin's second messenger in a subcellular system.通过直接向分离的质膜/线粒体混合物中添加胰岛素来激活丙酮酸脱氢酶：亚细胞系统中胰岛素第二信使生成的证据。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):77-81. doi: 10.1073/pnas.77.1.77.
9
Insulin receptor: structure and function.胰岛素受体：结构与功能
Endocr Rev. 1981 Summer;2(3):251-63. doi: 10.1210/edrv-2-3-251.
10
Transport adenosine triphosphatases: properties and functions.转运ATP酶：特性与功能
Physiol Rev. 1981 Jan;61(1):1-76. doi: 10.1152/physrev.1981.61.1.1.

胰岛素作用的潜在介质：丙酮酸脱氢酶和腺苷酸环化酶活性的调节

Putative mediators of insulin action: regulation of pyruvate dehydrogenase and adenylate cyclase activities.

作者信息

Saltiel A R, Siegel M I, Jacobs S, Cuatrecasas P

出版信息

Proc Natl Acad Sci U S A. 1982 Jun;79(11):3513-7. doi: 10.1073/pnas.79.11.3513.

DOI:10.1073/pnas.79.11.3513
PMID:7048309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC346451/
Abstract

Recent evidence suggests that certain actions of insulin may be mediated by the selective generation of chemically undefined intracellular substances. Incubation of rat liver particulate fraction with low concentrations of insulin enhances the release into the supernatant of a substance that stimulates mitochondrial pyruvate dehydrogenase. Higher concentrations of insulin release less stimulating activity. It is possible to resolve activities that stimulate and inhibit pyruvate dehydrogenase by differential ethanol extraction of the supernatant solutions. The elaboration of both factors is dependent upon the presence of insulin in a dose-dependent manner. Moreover, fractions that contain the pyruvate dehydrogenase-inhibiting activity also inhibit adipocyte basal and hormonally stimulated adenylate cyclase. The production of this adenylate cyclase inhibitory activity is also stimulated by insulin. Cyclase inhibition is virtually abolished when the nonhydrolyzable ATP analog, 5'-adenylyl imidodiphosphate, is included in the assay. These results indicate that the bimodal effects of insulin on certain functions may be ascribed to the generation of at least two distinct chemical substances that show opposing activities, which may operate by regulating phosphorylation reactions.

摘要

最近的证据表明，胰岛素的某些作用可能是由化学性质不明确的细胞内物质的选择性生成介导的。用低浓度胰岛素孵育大鼠肝脏微粒体部分，会增强一种刺激线粒体丙酮酸脱氢酶的物质释放到上清液中。较高浓度的胰岛素释放的刺激活性较低。通过对上清液进行不同的乙醇提取，可以分离出刺激和抑制丙酮酸脱氢酶的活性。这两种因子的产生都以剂量依赖的方式依赖于胰岛素的存在。此外，含有丙酮酸脱氢酶抑制活性的部分也会抑制脂肪细胞的基础和激素刺激的腺苷酸环化酶。这种腺苷酸环化酶抑制活性的产生也受到胰岛素的刺激。当在测定中加入不可水解的ATP类似物5'-腺苷酰亚胺二磷酸时，环化酶抑制几乎被消除。这些结果表明，胰岛素对某些功能的双峰效应可能归因于至少两种具有相反活性的不同化学物质的产生，它们可能通过调节磷酸化反应起作用。