Al-Damluji S F, Al-Khalidi A, Shaarbaf H, Tawfiq N H
Pharmatherapeutica. 1982;3(2):133-9.
An open crossover study was carried out in 10 Arab patients with mild to moderate hypertension to compare the effectiveness and tolerability of labetalol with alpha-methyldopa. Patients were started on either 100 mg labetalol or 250 mg alpha-methyldopa 3-times daily and, if necessary, the dosage adjusted by standard increments every 2 weeks over a period of a month until satisfactory control was achieved. This dosage was then maintained for a further 6 weeks before the patients were crossed over to the alternative treatment, similarly adjusted, after a wash-out period of 2 weeks on placebo. The results showed that both treatments produced effective blood pressure control and there was no significant difference in the maximum reduction achieved. The effect of the two drugs on heart rate was also similar. Both treatments were generally well-tolerated and side-effects were mild and similar with either drug.
对10名轻度至中度高血压的阿拉伯患者进行了一项开放性交叉研究，以比较拉贝洛尔与α-甲基多巴的有效性和耐受性。患者开始时每日3次服用100毫克拉贝洛尔或250毫克α-甲基多巴，必要时，在一个月的时间内每2周按标准增量调整剂量，直至实现满意的血压控制。然后维持该剂量6周，之后患者在接受2周安慰剂洗脱期后，交叉接受同样调整的替代治疗。结果显示，两种治疗均能有效控制血压，最大降幅无显著差异。两种药物对心率的影响也相似。两种治疗总体耐受性良好，副作用轻微，且两种药物的副作用相似。
