McMahon J E
Tropenmed Parasitol. 1981 Dec;32(4):250-2.
Field trials in which spaced doses of DEC were given once weekly, monthly or bi-monthly (or combinations of these intervals) cleared microfilariae (mf) of Wuchereria bancrofti from the blood in 78% if persons examined at six months. This reduction of microfilaraemia was maintained at a four years follow up examination. All regimens were well tolerated. In areas where mf rates were less than 12% a total dose of 36-48 mg/kg of DEC was effective. Higher doses (72 mg/kg) are required where mf rates are greater than 20%. The results of administering an oral dose of levamisole (3 mg/kg) prior to daily doses of DEC (6 mg/kg/day/7) were no better at the 2 month examination compared to the results following a similar regimen of DEC without prior administration of levamisole. Retreatment with DEC (6 mg/kg/day/7) of persons having microfilaraemia four years after initial treatment with this drug resulted in mf clearance in 94% of subjects.
现场试验中，按每周、每月或每两个月（或这些间隔的组合）间隔给予乙胺嗪（DEC），六个月时接受检查的人群中，78%的人血液中的班氏吴策线虫微丝蚴（mf）被清除。这种微丝蚴血症的降低在四年的随访检查中得以维持。所有治疗方案耐受性良好。在微丝蚴率低于12%的地区，36 - 48毫克/千克的乙胺嗪总剂量有效。微丝蚴率高于20%的地区则需要更高剂量（72毫克/千克）。与未预先服用左旋咪唑而采用类似乙胺嗪治疗方案的结果相比，在每日服用乙胺嗪（6毫克/千克/天/7天）之前先口服一剂左旋咪唑（3毫克/千克），在两个月检查时效果并无更好。初次使用该药物治疗四年后仍有微丝蚴血症的人，再次用乙胺嗪（6毫克/千克/天/7天）治疗，94%的受试者微丝蚴被清除。
