Narasimham M V, Roychowdhury S P, Das M, Rao C K
Southeast Asian J Trop Med Public Health. 1978 Dec;9(4):571-5.
Levamisole and mebendazole, broad spectrum anthelminthic compounds were tested against microfilaria of Wuchereria bancrofti, and the results were compared with similarly treated diethylcarbamazine and untreated group. Levamisole at a dosage of 3 mg/kg daily for 8 days showed marked reduction in both microfilaria rate and microfilaria density and immediately thereafter mf-rate steadily increased almost up to pre-treatment level, the mf-density however showed only marginal increase. Mebendazole at dosage of 6 mg/kg daily for 10 days following 8 days treatment of levamisole also showed marginal increase of mf-rate but no increase of mf-density. Treatment with DEC at a dosage of 6 mg/kg daily for 12 days showed comparatively better results both in respect of reduction in mf-rate and mf-density. The reactions - severity and duration were more among levamisole treated groups as compared to DEC treated group. Thus with the dosages tried, DEC could be considered as a better drug than levamisole and mebendazole. Both the latter compounds had no or very limited effect on the adult worms of W. bancrofti.
对广谱驱虫化合物左旋咪唑和甲苯咪唑进行了抗班氏吴策线虫微丝蚴的试验，并将结果与经同样处理的乙胺嗪及未处理组进行了比较。左旋咪唑以每日3毫克/千克的剂量给药8天，微丝蚴率和微丝蚴密度均显著降低，此后微丝蚴率立即稳步上升，几乎达到治疗前水平，而微丝蚴密度仅略有增加。在左旋咪唑治疗8天后，甲苯咪唑以每日6毫克/千克的剂量给药10天，微丝蚴率也仅有轻微增加，但微丝蚴密度未增加。乙胺嗪以每日6毫克/千克的剂量给药12天，在降低微丝蚴率和微丝蚴密度方面显示出相对较好的效果。与乙胺嗪治疗组相比，左旋咪唑治疗组的反应——严重程度和持续时间更大。因此，就所试用的剂量而言，乙胺嗪可被认为是比左旋咪唑和甲苯咪唑更好的药物。后两种化合物对班氏吴策线虫成虫没有或只有非常有限的作用。
