Mak J W, Zaman V
Trans R Soc Trop Med Hyg. 1980;74(3):285-91. doi: 10.1016/0035-9203(80)90081-4.
Seventy-eight microfilaraemic patients with Wuchereria bancrofti and Brugia malayi infections were treated with various oral levamisole hydrochloride total dosage regimes of 150 to 3,150 mg and total diethylcarbamazine citrate (DEC) of 36 and 126 mg per kg body-weight. Significant microfilaricidal and probable macrofilaricidal effects were seen at total levamisole hydrochloride dosages of 300 to 3,150 mg and the DEC dosages. The optimum dosage regime with levamisole hydrochloride recommended for treatment of microfilaraemic patients is 100 mg initially followed by 100 mg twice daily for 10 days. This dosage regime was as effective as a total oral dosage of DEC at 126 mg per kg body-weight. Side reactions were dose-dependent, mild and transient, with fever being the most common. One patient developed fits after 150 mg levamisole hydrochloride. The pathophysiology of these side reactions is discussed and it is recommended that levamisole hydrochloride, as a probable alternative for the treatment of patent and occult filariasis, should be used only under close medical supervision.
78例感染班氏吴策线虫和马来布鲁线虫的微丝蚴血症患者接受了各种口服盐酸左旋咪唑治疗方案，总剂量为150至3150毫克，枸橼酸乙胺嗪（DEC）总剂量为每公斤体重36毫克和126毫克。在盐酸左旋咪唑总剂量为300至3150毫克以及DEC剂量下，观察到了显著的杀微丝蚴作用和可能的杀成虫作用。推荐用于治疗微丝蚴血症患者的盐酸左旋咪唑最佳剂量方案是初始剂量100毫克，随后每日两次，每次100毫克，共10天。该剂量方案与每公斤体重126毫克的DEC口服总剂量效果相同。副作用与剂量相关，轻微且短暂，发热最为常见。1例患者在服用150毫克盐酸左旋咪唑后出现惊厥。讨论了这些副作用的病理生理学，并建议盐酸左旋咪唑作为治疗显性和隐性丝虫病的一种可能替代药物，仅应在密切医疗监督下使用。
