感染莱氏无胆甾原体细胞和劳斯氏病毒的小鼠脾脏淋巴细胞的免疫和功能活性。
Immunological and functional activity of spleen lymphocytes from mice infected by Acholeplasma laidlawii cells and Rauscher virus.
作者信息
Rakovskaya I V, Sanin A V, Konstantinova N D, Ladygina V G, Migoushina V L, Tarshis M A
出版信息
Zentralbl Bakteriol Mikrobiol Hyg A Med Mikrobiol Infekt Parasitol. 1982 Apr;251(4):545-53.
The duration of Acholeplasma laidlawii antigen persistence in mice, resistant to Rausher leukemia virus, after infection with both A. laidlawii cells and Rausher virus has been studied. The antigen persistence was accompanied by marked depression of immune response which was especially severe in case of mixed acholeplasmavirus infection. Such immunosuppression and observed infiltration of the spleen with immature leukemic cells can be regarded as a preleukosis. Immunosuppression was accompanied by an increase of the transport of carbohydrates inthe lymphocytes. This stimulation an be explained by the exchange of lipid components between acholeplasma and lymphocyte membranes resulted in increase of lymphocyte membrane fluidity, or it may be due to the mitogenic effect of A. laidlawii cells and virus, accompanied by the same membrane effect.
研究了对劳舍尔白血病病毒有抗性的小鼠在感染莱氏无胆甾原体细胞和劳舍尔病毒后，莱氏无胆甾原体抗原在小鼠体内持续存在的时间。抗原持续存在伴随着免疫反应的显著抑制，在无胆甾原体病毒混合感染的情况下尤其严重。这种免疫抑制以及观察到的脾脏被未成熟白血病细胞浸润可被视为白血病前期。免疫抑制伴随着淋巴细胞中碳水化合物转运的增加。这种刺激可以解释为无胆甾原体与淋巴细胞膜之间脂质成分的交换导致淋巴细胞膜流动性增加，或者可能是由于莱氏无胆甾原体细胞和病毒的促有丝分裂作用，伴随着相同的膜效应。
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