Crane L R, Levy H B, Lerner A M
Antimicrob Agents Chemother. 1982 Mar;21(3):481-5. doi: 10.1128/AAC.21.3.481.
Polyriboinosinic-polyribocytidylic acid complexed with poly-l-lysine and carboxymethylcellulose [poly(ICLC)] is a potent interferon inducer when given parenterally to humans. Topical application in animal models has shown beneficial antiviral and clinical effects. In a randomized, double-blinded, placebo-controlled trial of topical poly(ICLC) in recurrent genital herpes simplex virus infection, five clinical and two virological parameters were followed. Fifty-seven men and women, with 78 recurrences of genital herpes, were stratified by sex. No clinical or antiviral differences between poly(ICLC) and placebo groups in either stratum were found. Further analysis of male subgroups by age and size of lesions showed no changes in the rapidity of healing or viral shedding.
与聚-L-赖氨酸和羧甲基纤维素复合的聚肌苷酸-聚胞苷酸[聚（ICLC）]，经肠胃外给药于人体时是一种有效的干扰素诱导剂。在动物模型中的局部应用已显示出有益的抗病毒和临床效果。在一项关于复发性生殖器单纯疱疹病毒感染局部应用聚（ICLC）的随机、双盲、安慰剂对照试验中，对五个临床参数和两个病毒学参数进行了跟踪。57名男性和女性，共出现78次生殖器疱疹复发，按性别分层。在任何一层中，聚（ICLC）组和安慰剂组之间均未发现临床或抗病毒方面的差异。按年龄和皮损大小对男性亚组进行的进一步分析显示，愈合速度或病毒排出情况没有变化。
