Spruance S L, Crumpacker C S, Haines H, Bader C, Mehr K, MacCalman J, Schnipper L E, Klauber M R, Overall J C
N Engl J Med. 1979 May 24;300(21):1180-4. doi: 10.1056/NEJM197905243002103.
The ability of topical 10 per cent adenine arabinoside 5'-monophosphate to decrease the severity and frequency of recurrent herpes simplex labialis was evaluated in a double-blind, randomized study of 233 patients at three collaborating institutions. Nine clinical and four virologic measurements were used to evaluate drug efficacy during a single episode. No statistically significant improvement in any measurement was seen in the drug-treated patients. Analyses according to institution and age, stage and size of lesion before therapy also indicated no benefit attributable to the drug. There was no effect of the drug on the rate of recurrence of herpes simplex labialis. We conclude that, despite activity against herpes simplex virus infection in tissue culture and in some laboratory animal models, topical use of the drug is ineffective against recurrent herpes simplex labialis. This may be due to failure of the drug to penetrate the skin.
在三个合作机构对233例患者进行的一项双盲、随机研究中，评估了局部应用10%阿糖腺苷5'-单磷酸降低复发性唇疱疹严重程度和发作频率的能力。在单次发作期间，使用了9项临床指标和4项病毒学指标来评估药物疗效。在接受药物治疗的患者中，任何指标均未观察到具有统计学意义的改善。根据机构以及治疗前病变的年龄、阶段和大小进行的分析也表明，该药物没有带来益处。该药物对唇疱疹的复发率没有影响。我们得出结论，尽管该药物在组织培养和一些实验动物模型中对单纯疱疹病毒感染有活性，但局部使用该药物对复发性唇疱疹无效。这可能是由于该药物未能穿透皮肤。
