Mucklow J C
J Clin Hosp Pharm. 1982 Jun;7(2):79-85. doi: 10.1111/j.1365-2710.1982.tb01007.x.
Our ability to measure plasma drug concentrations under steady-state conditions has meant that the daily dose of phenytoin, and a few other anticonvulsants drugs, can be safely adjusted to suit the individual epileptic's seizure pattern and drug metabolizing capacity. With correct timing of samples and interpretation of results, therapeutic drug monitoring can lead to, and maintain, complete freedom from seizures for some patients and an appreciable reduction in frequency for many others. There are large numbers of epileptics, however, who continue to suffer needlessly because clinical practice has lagged behind our expertise in drug assay and our understanding of pharmacokinetics. We are not using our knowledge sufficiently to benefit the epileptic population as a whole.
我们在稳态条件下测量血浆药物浓度的能力意味着，苯妥英钠以及其他一些抗惊厥药物的日剂量可以安全地调整，以适应个体癫痫患者的发作模式和药物代谢能力。通过正确的采样时间和结果解读，治疗药物监测可以使一些患者实现并维持完全无癫痫发作，使许多其他患者的发作频率显著降低。然而，仍有大量癫痫患者在不必要地受苦，因为临床实践落后于我们在药物检测方面的专业知识以及我们对药代动力学的理解。我们没有充分利用我们的知识来使整个癫痫患者群体受益。
