Levitt P, Cooper M L, Rakic P
J Neurosci. 1981 Jan;1(1):27-39. doi: 10.1523/JNEUROSCI.01-01-00027.1981.
The cytological composition of the proliferative zones in the fetal monkey occipital lobe was examined at the light and electron microscopic levels by immunoperoxidase localization of glial fibrillary acid protein (GFA), a protein that is present in astrocytes and radial glial cells but not neurons. During the peak of neurogenesis at embryonic day 80, two distinct classes of proliferative cells, GFA-positive and GFA-negative, are intermixed in the ventricular and subventricular zones. Both cell types are readily recognized in different phases of the mitotic cycle along the ventricular surface. The results indicate that, contrary to prevailing views, (1) glial and neuronal cell lines coexist within the fetal proliferative zones and (2) the onset of glial phenotypic expression occurs prior to the last cell division.
通过对胶质纤维酸性蛋白（GFA）进行免疫过氧化物酶定位，在光镜和电镜水平上检查了胎猴枕叶增殖区的细胞组成。GFA是一种存在于星形胶质细胞和放射状胶质细胞而非神经元中的蛋白质。在胚胎第80天神经发生的高峰期，两类不同的增殖细胞，即GFA阳性和GFA阴性细胞，在脑室区和脑室下区混合存在。沿着脑室表面，这两种细胞类型在有丝分裂周期的不同阶段都很容易识别。结果表明，与普遍观点相反，（1）胶质细胞系和神经元细胞系在胎儿增殖区内共存，（2）胶质细胞表型表达的开始发生在最后一次细胞分裂之前。
