抗P1，与东南亚患者华支睾吸虫和麝猫后睾吸虫感染相关的同种血凝素。

Anti-P1, allohemagglutinins associated with Clonorchis sinensis and opisthorchis viverrini infections in patients from Southeast Asia.

作者信息

Ben-Ismail R, Druilhe P, Mogahed A, Tharavanij S, Gentilini M

出版信息

Southeast Asian J Trop Med Public Health. 1982 Mar;13(1):86-90.

Abstract

An automated assay of anti-P1 allohemagglutinins has been carried out on sera of 61 individuals from Southeast Asia : 28 with clonorchiasis, 18 with opisthorchiasis and 15 control subjects. Anti-P1 activity was detected in 61% of the opisthorchiasis sera, 57% of the clonorchiasis sera and in 26.6% of the control subjects. Their concentration, in the sera, was low in control subjects and exceptionally high in clonorchiasis and opisthorchiasis (up to 13 and 22 times the maximum concentration of the control subjects, respectively). In all cases the anti-P1 antibodies were of IgM class. The results suggested that Clonorchis and Opisthorchis were responsible for immunization of the patients, with P1 alloantigen.

摘要

对来自东南亚的61个人的血清进行了抗P1同种血凝素的自动化检测：28例华支睾吸虫病患者、18例后睾吸虫病患者和15名对照者。在后睾吸虫病血清中，61%检测到抗P1活性；华支睾吸虫病血清中，57%检测到抗P1活性；对照者中，26.6%检测到抗P1活性。对照者血清中其浓度较低，而在华支睾吸虫病和后睾吸虫病患者中异常高（分别高达对照者最大浓度的13倍和22倍）。所有病例中，抗P1抗体均为IgM类。结果表明，华支睾吸虫和后睾吸虫是患者针对P1同种抗原产生免疫反应的原因。