Feldmeier H, Doehring E, Daffalla A A, Omer A H, Dietrich M
Tropenmed Parasitol. 1982 Jun;33(2):102-6.
In a prospective clinical trial, patients with urinary schistosomiasis from the Sudan and from other African countries were treated with two or three doses of metrifonate (10 mg/kg), respectively, in two weeks' intervals. Patients seen in the Sudan (n = 37) were followed up for 3 months, those seen in Hamburg (n = 17) up to 20 months. Each dose of metrifonate led to a decrease of almost 90% in egg excretion independently of the pretreatment intensity of infection so that after three doses a reduction of almost 99.9% was achieved. The estimated proportion of parasitological cure after two doses of metrifonate was in the order of 24% in the lightly infected patients seen in Hamburg, and in the order of 8% in the heavily infected Sudanese patients. Almost 59% of the patients who received a complete metrifonate treatment of three doses stopped to excrete ova of S. haematobium. Drug failure was found in almost the same proportion in the two patient groups (17.5% and 16.2%, respectively) and could not be overcome by additional doses of metrifonate. The considerable reduction in egg excretion after a single dose of metrifonate might have a remarkable benefit in large scale programmes where the aim is drastic reduction of worm burden rather than complete cure.
在一项前瞻性临床试验中，来自苏丹和其他非洲国家的泌尿血吸虫病患者分别每隔两周接受两剂或三剂敌百虫（10毫克/千克）治疗。在苏丹就诊的患者（n = 37）随访3个月，在汉堡就诊的患者（n = 17）随访长达20个月。每剂敌百虫均使虫卵排泄量减少近90%，与治疗前的感染强度无关，因此三剂治疗后虫卵排泄量减少了近99.9%。在汉堡轻度感染患者中，两剂敌百虫治疗后的寄生虫学治愈率估计约为24%，在苏丹重度感染患者中约为8%。几乎59%接受三剂敌百虫完整治疗的患者停止排出埃及血吸虫虫卵。两个患者组的药物治疗失败比例几乎相同（分别为17.5%和16.2%），额外剂量的敌百虫无法克服这一问题。在旨在大幅减轻蠕虫负担而非彻底治愈的大规模项目中，单剂敌百虫后虫卵排泄量的显著减少可能具有显著益处。
