Haldén E
Acta Anaesthesiol Scand. 1982 Jun;26(3):209-12. doi: 10.1111/j.1399-6576.1982.tb01755.x.
The validity of the transcutaneous oxygen tension (PaO2) method as opposed to measurement of arterial oxygen tension (PaO2) and mixed venous oxygen saturation (SVO2), for monitoring optimal oxygen transport, was studied in six mechanically ventilated pigs with an oleic acid lung injury. With stepwise increments in positive end-expiratory pressure (PEEP) from zero to 20 cmH2O maximum oxygen flux was found at a PEEP of 8 cmH2O and named "optimal PEEP". With increasing PEEP, cardiac output (CO) was maintained up to a PEEP of 8 cmH2O, when it began to decline, while venous admixture decreased at all respiratory settings up to a PEEP of 16, when it was about one-fourth of the value (38.7%) at a PEEP of zero. PaO2 increased with rising PEEP and reached a steady level at a PEEP of 16 cmH2O. PtCO2 and SVO2 parallelled each other and rose steeply up to a PEEP of 8 cmH2O. They showed a further slight increase up to a PEEP of 12 and after that a tendency to decrease. It is concluded that PtCO2 and SVO2 both seem to distinguish the optimal PEEP and give more adequate information than does PaO2. The PtCO2 method has the advantage of being non-invasive.
在六只患有油酸肺损伤的机械通气猪中，研究了经皮氧分压（PtCO2）法相对于动脉血氧分压（PaO2）和混合静脉血氧饱和度（SVO2）测量在监测最佳氧输送方面的有效性。随着呼气末正压（PEEP）从零逐步增加到20 cmH2O，在8 cmH2O的PEEP时发现最大氧通量，并将其命名为“最佳PEEP”。随着PEEP增加，心输出量（CO）在PEEP达到8 cmH2O之前保持不变，之后开始下降，而静脉混合血在所有呼吸设置下直至16 cmH2O的PEEP时均下降，此时约为PEEP为零时值（38.7%）的四分之一。PaO2随着PEEP升高而增加，并在16 cmH2O的PEEP时达到稳定水平。PtCO2和SVO2相互平行，在PEEP达到8 cmH2O之前急剧上升。它们在PEEP达到12 cmH2O之前进一步略有增加，之后呈下降趋势。结论是，PtCO2和SVO2似乎都能区分最佳PEEP，并且比PaO2提供更充分的信息。PtCO2法具有非侵入性的优点。
