内毒素对大鼠肝脏脂质过氧化物水平以及肝脏和血浆锌浓度的影响与给药后的时间关系。
The effect of endotoxin on the liver lipid peroxide level and on the liver and plasma zinc concentrations in rats as related to time after administration.
作者信息
Sankari S, Pekkanen T
出版信息
Acta Vet Scand. 1982;23(1):24-9. doi: 10.1186/BF03546818.
The lipid peroxide level of rat liver increased due to i.p. endotoxin injection, reaching its maximum, value 24 h after administration. After that the level declined, reaching approximately the initial value at 48 h. The liver Zn concentration increased and the plasma Zn concentration rapidly decreased after the injection. The liver Zn concentration then gradually declined and the plasma Zn respectively increased near the initial level 48 h after the injection. The highest lipid peroxide level occurred at 24 h when the mean Zn concentration of the plasma and liver were already relatively near the initial level, suggesting a regulative role of Zn in lipid peroxidation.
腹腔注射内毒素后，大鼠肝脏的脂质过氧化物水平升高，给药后24小时达到最大值。此后该水平下降，在48小时时降至接近初始值。注射后肝脏锌浓度升高，血浆锌浓度迅速下降。然后肝脏锌浓度逐渐下降，血浆锌在注射后48小时分别升至接近初始水平。脂质过氧化物水平最高值出现在24小时，此时血浆和肝脏的平均锌浓度已相对接近初始水平，提示锌在脂质过氧化中起调节作用。
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