细菌内毒素对小鼠体温、血浆锌及急性期蛋白血清淀粉样P成分血浆浓度的影响。
Effect of bacterial endotoxin on body temperature, plasma zinc and plasma concentrations of the acute-phase protein serum amyloid p component in mice.
作者信息
Poole S, Gordon A H, Baltz M, Stenning B E
出版信息
Br J Exp Pathol. 1984 Aug;65(4):431-9.
Abstract
Bacterial endotoxin and lipid A evoked dose-dependent increases in body temperature and plasma SAP concentrations and dose-dependent falls in plasma zinc concentrations in mice. The respective sensitivities of the three variables to lipid A or to whole endotoxin had the relation SAP greater than Zinc much greater than body temperature; zinc and SAP responses were evoked by less than 1 ng lipid A/endotoxin. Pretreatment with indomethacin prevented only the temperature response to lipid A. Pretreatment with dexamethasone did not affect the temperature response but diminished the zinc response and enhanced the SAP response to lipid A.
摘要
细菌内毒素和脂多糖可引起小鼠体温和血浆血清淀粉样蛋白P（SAP）浓度呈剂量依赖性升高，以及血浆锌浓度呈剂量依赖性降低。这三个变量对脂多糖或全内毒素的各自敏感性关系为：SAP大于锌大于体温；低于1 ng脂多糖/内毒素即可引发锌和SAP反应。吲哚美辛预处理仅能阻止对脂多糖的体温反应。地塞米松预处理不影响体温反应，但可减弱锌反应，并增强对脂多糖的SAP反应。
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本文引用的文献
1
Lack of correlation between zinc, copper and C-reactive protein in human serum.
Proc Soc Exp Biol Med. 1962 Jul;110:450-1. doi: 10.3181/00379727-110-27546.
2
Studies on the pathogenesis of fever. XI. Quantitative features of the febrile response to leucocytic pyrogen.
J Exp Med. 1963 Mar 1;117(3):349-64. doi: 10.1084/jem.117.3.349.
3
Role of the central nervous system in acute-phase responses to leukocytic pyrogen.
Infect Immun. 1980 Nov;30(2):439-44. doi: 10.1128/iai.30.2.439-444.1980.
4
The site of action of corticosteroid antipyresis in the rabbit.
J Physiol. 1980 Mar;300:1-6. doi: 10.1113/jphysiol.1980.sp013146.
5
The pyrogenic and mitogenic actions of interleukin-1 are related.
Nature. 1983;304(5925):449-51. doi: 10.1038/304449a0.
6
Effect of ibuprofen on fever and metabolic changes induced by continuous infusion of leukocytic pyrogen (interleukin 1) or endotoxin.
Infect Immun. 1983 Dec;42(3):997-1005. doi: 10.1128/iai.42.3.997-1005.1983.
7
Relationship of trace metals to fever during infection: are prostaglandins involved?
Am J Physiol. 1983 Mar;244(3):R368-73. doi: 10.1152/ajpregu.1983.244.3.R368.
8
Identification of glucocorticoid-induced genes in rat hepatoma cells by isolation of cloned cDNA sequences.
Proc Natl Acad Sci U S A. 1983 Aug;80(16):5042-6. doi: 10.1073/pnas.80.16.5042.
9
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
Nat New Biol. 1971 Jun 23;231(25):232-5. doi: 10.1038/newbio231232a0.
10
Characterization of the endogenous mediator(s) of serum zinc and iron depression during infection and other stresses.
Proc Soc Exp Biol Med. 1971 Nov;138(2):728-32. doi: 10.3181/00379727-138-35977.
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