Poole S, Gordon A H, Baltz M, Stenning B E
Br J Exp Pathol. 1984 Aug;65(4):431-9.
Bacterial endotoxin and lipid A evoked dose-dependent increases in body temperature and plasma SAP concentrations and dose-dependent falls in plasma zinc concentrations in mice. The respective sensitivities of the three variables to lipid A or to whole endotoxin had the relation SAP greater than Zinc much greater than body temperature; zinc and SAP responses were evoked by less than 1 ng lipid A/endotoxin. Pretreatment with indomethacin prevented only the temperature response to lipid A. Pretreatment with dexamethasone did not affect the temperature response but diminished the zinc response and enhanced the SAP response to lipid A.
细菌内毒素和脂多糖可引起小鼠体温和血浆血清淀粉样蛋白P（SAP）浓度呈剂量依赖性升高，以及血浆锌浓度呈剂量依赖性降低。这三个变量对脂多糖或全内毒素的各自敏感性关系为：SAP大于锌大于体温；低于1 ng脂多糖/内毒素即可引发锌和SAP反应。吲哚美辛预处理仅能阻止对脂多糖的体温反应。地塞米松预处理不影响体温反应，但可减弱锌反应，并增强对脂多糖的SAP反应。
