Mahajan S K, Abbasi A A, Prasad A S, Rabbani P, Briggs W A, McDonald F D
Ann Intern Med. 1982 Sep;97(3):357-61. doi: 10.7326/0003-4819-97-3-357.
Zinc deficiency may account for the persistence of gonadal dysfunction in a majority of uremic men despite adequate dialysis. Twenty stable patients having hemodialysis three times a week completed a double-blind trial using either 50 mg of elemental zinc as zinc acetate (10 patients) or placebo (10 patients), orally. At the end of the 6-month study period, a significant increase in the mean (+/- SE) plasma zinc (75 +/- 2 micrograms/dL to 100 +/- 2 micrograms/dL, p less than 0.001), serum testosterone (2.8 +/- 0.3 ng/dL to 5.2 +/- 0.5 ng/mL, p less than 0.001), and sperm count (30 +/- 3 million/mL to 63 +/- 5 million/mL, p less than 0.001) occurred in the zinc-treated group, but not in those receiving the placebo. The zinc-treated group also had a significant fall in serum luteinizing hormone (92 +2- 10 mIU/mL to 49 +/- 26 mIU/mL, p less than 0.005) and follicle stimulating hormone (45 +/- 9 mIU/mL to 25 +/- 7 mIU/mL, p less than 0.05), not seen in the placebo group. Patients receiving zinc had an improvement in potency, libido, and frequency of intercourse not found in the placebo group. These results suggest that zinc deficiency is a reversible cause of gonadal dysfunction in patients having regular hemodialysis.
尽管进行了充分的透析，但锌缺乏可能是大多数尿毒症男性性腺功能障碍持续存在的原因。20名每周进行三次血液透析的稳定患者完成了一项双盲试验，其中10名患者口服50毫克元素锌（以醋酸锌形式），另外10名患者口服安慰剂。在6个月的研究期结束时，锌治疗组的平均（±标准误）血浆锌显著增加（从75±2微克/分升降至100±2微克/分升，p<0.001）、血清睾酮显著增加（从2.8±0.3纳克/分升降至5.2±0.5纳克/毫升，p<0.001）以及精子计数显著增加（从30±3百万/毫升增至63±5百万/毫升，p<0.001），而接受安慰剂的组未出现这些变化。锌治疗组的血清促黄体生成素也显著下降（从92±10毫国际单位/毫升降至49±26毫国际单位/毫升，p<0.005）以及促卵泡激素显著下降（从45±9毫国际单位/毫升降至25±7毫国际单位/毫升，p<0.05），安慰剂组未出现这种情况。接受锌治疗的患者在性功能、性欲和性交频率方面有所改善，而安慰剂组未出现这种情况。这些结果表明，锌缺乏是定期进行血液透析患者性腺功能障碍的一个可逆原因。
