Meberg A, Saugstad O D
Scand J Clin Lab Invest. 1978 Sep;38(5):437-40. doi: 10.1080/00365517809108448.
In forty-five children the hypoxanthine concentration in cerebrospinal fluid (CSF) was measured (fifty-two samples). In newborn infants (nineteen patients) the hypoxanthine levels were higher in patients with clinical conditions associated with hypoxia (idiopathic respiratory distress syndrome, asphyxia, apneic attacks) than in patients without clinical hypoxia (P less than 0.01). In hypoxic patients the hypoxanthine concentration varied between 5 and 28 mu mol/l. In children outside the neonatal period the hypoxanthine concentration in CSF varied considerably in different diseases. High levels were registered in meningitis prior to treatment, febrile convulsions and in lymphoblastic leukaemia, probably reflecting tissue hypoxia and an increased tissue catabolism.
对45名儿童的脑脊液（CSF）中的次黄嘌呤浓度进行了测量（共52份样本）。在新生儿（19例患者）中，患有与缺氧相关临床病症（特发性呼吸窘迫综合征、窒息、呼吸暂停发作）的患者的次黄嘌呤水平高于无临床缺氧的患者（P<0.01）。在缺氧患者中，次黄嘌呤浓度在5至28μmol/L之间变化。在新生儿期以外的儿童中，不同疾病的脑脊液中次黄嘌呤浓度差异很大。在治疗前的脑膜炎、热性惊厥和淋巴细胞白血病中记录到高水平，这可能反映了组织缺氧和组织分解代谢增加。
