Livingston J H, Brown J K, Harkness R A, McCreanor G M, O'Hare A E
Department of Paediatric Neurology, Royal Hospital for Sick Children, Edinburgh.
Dev Med Child Neurol. 1989 Apr;31(2):161-7. doi: 10.1111/j.1469-8749.1989.tb03974.x.
Cerebrospinal fluid (CSF) markers of cerebral energy depletion were measured in 32 infants and children following short (less than 10 minutes) febrile convulsions, and in 19 controls. Specific and sensitive indices of high-energy phosphate compound depletion (hypoxanthine, xanthine and uridine) showed no marked changes. Values for patients and febrile controls were significantly higher than for afebrile controls, which is consistent with increased cerebral metabolism in febrile patients. There were no differences in pH, lactate or creatine kinase levels in the CSF of patients and controls. The results suggest that short febrile convulsions are benign and that in the absence of risk factors for the subsequent development of epilepsy, prophylactic anticonvulsant treatment is not indicated.
对32名婴幼儿和儿童在短时间（少于10分钟）热性惊厥后以及19名对照者进行了脑能量消耗的脑脊液（CSF）标志物检测。高能磷酸化合物消耗的特异性和敏感性指标（次黄嘌呤、黄嘌呤和尿苷）未显示出明显变化。患者和热性对照者的值显著高于无热对照者，这与发热患者脑代谢增加一致。患者和对照者脑脊液中的pH值、乳酸或肌酸激酶水平没有差异。结果表明，短时间热性惊厥是良性的，并且在没有后续癫痫发作风险因素的情况下，不建议进行预防性抗惊厥治疗。
