Rootwelt K, Solberg H E
Scand J Clin Lab Invest. 1978 Sep;38(5):477-85. doi: 10.1080/00365517809108454.
In 430 patients with a variety of thyroid disorders, linear discriminant analysis was used to select laboratory test combinations giving optimum diagnostic efficiency in thyroid function studies. Unexpectedly, TSH was found valuable in the diagnosis of hyperthyroidism and T3 in hypothyroidism. These test combinations were found optimal for the separation of euthyroidism/hyperthyroidism: T3, TSH and T4; euthyroidism/hypothyroidism: Combined free thyroid hormone index (FTI) and TSH; and hyperthyroidism/euthyroidism/hypothyroidism: T3, TSH, T4, FTI and T3U. The latter test combination had a total efficiency of 94%. Cholesterol, achilles reflex time, PBI and radioiodine uptake measurement contributed little to the discrimination.
在430例患有各种甲状腺疾病的患者中，采用线性判别分析来选择在甲状腺功能研究中具有最佳诊断效率的实验室检查组合。出乎意料的是，发现促甲状腺激素（TSH）在甲亢诊断中有价值，而三碘甲状腺原氨酸（T3）在甲减诊断中有价值。这些检查组合对于区分甲状腺功能正常/甲亢是最佳的：T3、TSH和T4；甲状腺功能正常/甲减：游离甲状腺激素联合指数（FTI）和TSH；以及甲亢/甲状腺功能正常/甲减：T3、TSH、T4、FTI和T3U。后一种检查组合的总效率为94%。胆固醇、跟腱反射时间、蛋白结合碘（PBI）和放射性碘摄取测量对鉴别贡献不大。
