γ-氨基丁酸转氨酶的药物组织化学显示
The pharmacohistochemical demonstration of GABA-transaminase.
作者信息
Vincent S R, Kimura H, McGeer E G
出版信息
Neurosci Lett. 1980 Mar;16(3):345-8. doi: 10.1016/0304-3940(80)90023-3.
PMID:7052450
Abstract
A method for the histochemical demonstration of cells with the capacity to synthesize the enzyme GABA-transaminase is described. Intraventricular injection of ethanolamine-O-sulfate irreversibly inhibits brain GABA-transaminase activity. Within 17 h after the injection sufficient new enzyme is synthesized to allow histochemical visualization of positive soma against unstained neuropil. The implications of this technique for the anatomy of GABA systems is discussed.
摘要
本文描述了一种用于组织化学显示具有合成γ-氨基丁酸转氨酶能力的细胞的方法。脑室内注射乙醇胺-O-硫酸盐可不可逆地抑制脑γ-氨基丁酸转氨酶活性。注射后17小时内，会合成足够的新酶，从而能够在未染色的神经纤维网背景下对阳性胞体进行组织化学可视化。本文讨论了该技术对γ-氨基丁酸系统解剖学的意义。
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